Tactivin in the regulation of dexamethasone-induced apoptosis in thymocytes

被引：1

作者：

Arion, V. Ya. ^{[2
]}

Mel'nikova, V. I. ^{[1
]}

Afanas'eva, M. A. ^{[1
]}

Moskvina, S. N. ^{[1
]}

Zakharova, L. A. ^{[1
]}

机构：

[1] Russian Acad Sci, NK Koltsov Dev Biol Inst, Moscow, Russia

[2] Fed Agcy Hlth Care & Social Dev, Inst Physicochem Med, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2007年 / 144卷 / 03期

基金：

俄罗斯基础研究基金会;

关键词：

tactivin; apoptosis; thymocytes; rats; flow cytofluorometry;

D O I：

10.1007/s10517-007-0355-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

The level of natural apoptosis in rat thymus on day 18 of embryo development attained 25%, while at subsequent terms it was about 5%. In the spleen, this parameter gradually decreased from 15 to 37% starting from day 18 of embryo development to postnatal day 30. Tactivin prevented the development of dexamethasone-induced apoptosis in thymocytes of 30-day-old rats, but had no effect on spontaneous apoptosis. Tactivin can be used as a modulator of apoptotic processes.

引用

页码：479 / 481

页数：3

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