Oxidative stress and neurotoxicity

被引:652
作者
Sayre, Lawrence M. [1 ,2 ,3 ]
Perry, George [4 ]
Smith, Mark A. [2 ]
机构
[1] Case Western Reserve Univ, Dept Chem, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA
[3] Case Western Reserve Univ, Dept Environm Hlth Sci, Cleveland, OH 44106 USA
[4] Univ Texas San Antonio, Coll Sci, San Antonio, TX 78249 USA
关键词
D O I
10.1021/tx700210j
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
There is increasing awareness of the ubiquitous role of oxidative stress in neurodegenerative disease states. A continuing challenge is to be able to distinguish between oxidative changes that occur early in the disease from those that are secondary manifestations of neuronal degeneration. This perspective highlights the role of oxidative stress in Alzheimer's, Parkinson's, and Huntington's diseases, amyotrophic lateral sclerosis, and multiple sclerosis, neurodegenerative and neuroinflammatory disorders where there is evidence for a primary contribution of oxidative stress in neuronal death, as opposed to other diseases where oxidative stress more likely plays a secondary or by-stander role. We begin with a brief review of the biochemistry of oxidative stress as it relates to, mechanisms that lead to cell death, and why the central nervous system is particularly susceptible to such mechanisms. Following a review of oxidative stress involvement in individual disease states, some conclusions are provided as to what further research should hope to accomplish in the field.
引用
收藏
页码:172 / 188
页数:17
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