Involvement of nitric oxide on the peritoneal neutrophil influx induced by staphylococcal enterotoxin B in mouse

被引：11

作者：

Franco-Penteado, CF ^{[1
]}

DeSouza, I ^{[1
]}

Teixeira, S ^{[1
]}

Ribeiro-DaSilva, G ^{[1
]}

De Nucci, G ^{[1
]}

Antunes, E ^{[1
]}

机构：

[1] Univ Estadual Campinas, Dept Pharmacol, Fac Med Sci, BR-13081970 Campinas, SP, Brazil

来源：

TOXICON | 2001年 / 39卷 / 09期

基金：

巴西圣保罗研究基金会;

关键词：

enterotoxins; aminoguanidine; inflammation; nitric oxide synthases;

D O I：

10.1016/S0041-0101(01)00095-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this study, the role of nitric oxide (NO) on neutrophil migration induced by staphylococcal enterotoxin B (SEB) in the mouse peritoneal cavity was investigated. The NO synthase inhibitors L-NAME and aminoguanidine, as well as dexamethasone, markedly reduced SEE-induced neutrophil influx. In mice with an increased population of peritoneal macrophages, the inhibition of SEE-induced neutrophil influx by these agents was significantly lower. The in vivo treatment with aminoguanidine inhibited only the iNOS activity, whereas L-NAME inhibited both the cNOS and iNOS activities. In conclusion, NO modulates the neutrophil migration in response to SEE through the activity of an iNOS isoform. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1383 / 1386

页数：4

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