Cytotoxic geranyl stilbenes from Macaranga schweinfurthii

被引：98

作者：

Beutler, JA ^{[1
]}

Shoemaker, RH ^{[1
]}

Johnson, T ^{[1
]}

Boyd, MR ^{[1
]}

机构：

[1] NCI, Lab Drug Discovery Res & Dev, Dev Therapeut Program,Div Canc Treatment & Diag, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 12期

关键词：

D O I：

10.1021/np980208m

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three novel geranyl stilbenes, schweinfurthins A, B, and C (1, 2, and 3), were isolated from the Cameroonian plant Macaranga schweinfurthii (Euphorbiaceae) and their structures determined by NMR and mass spectral methods. The cytotoxicity profile of the schweinfurthins tested in the NCI 60-cell screen was similar to that of the stelletins and cephalostatins, suggesting that these structurally diverse natural products may share similar mechanisms of cytotoxicity.

引用

页码：1509 / 1512

页数：4

共 16 条

[1] DISTRIBUTION OF PHORBOL ESTER BIOACTIVITY IN THE EUPHORBIACEAE [J].

BEUTLER, JA ;

ALVARADO, AB ;

MCCLOUD, TG ;

CRAGG, GM .

PHYTOTHERAPY RESEARCH, 1989, 3 (05) :188-192

[2] Further studies on phorbol ester bioactivity in the Euphorbiaceae [J].

Beutler, JA ;

Lindner, ABA ;

McCloud, TG .

ANNALS OF THE MISSOURI BOTANICAL GARDEN, 1996, 83 (04) :530-533

[3]

BEUTLER JA, 1995, RECENT ADV PHYTOCHEM, V29, P47

[4]

BOYD MR, 1992, DEV ONCOL, V68, P11

[5]

Boyd MR, 1997, CANC DRUG DISCOVERY, P23

[6] PLANTS FROM NEW-CALEDONIA .133. A GERANYL SUBSTITUTED FLAVONOL FROM MACARANGA-VEDELIANA [J].

HNAWIA, E ;

THOISON, O ;

GUERITTEVOEGELEIN, F ;

BOURRET, D ;

SEVENET, T .

PHYTOCHEMISTRY, 1990, 29 (07) :2367-2368

[7] EXAMINATION OF EUPHORBIACEAE OF HONG-KONG .9. ISOLATION AND STRUCTURE OF MACARANGONOL, A DITERPENE KETOL FROM MACARANGA-TANARIUS [J].

HUI, WH ;

NG, KK ;

FUKAMIYA, N ;

KOREEDA, M ;

NAKANISH.K .

PHYTOCHEMISTRY, 1971, 10 (07) :1617-+

[8]

LIN JH, 1990, CHEM PHARM BULL, V38, P1218, DOI 10.1248/cpb.38.1218

[9] HIV inhibitory natural products .26. Quinoline alkaloids from Euodia roxburghiana [J].

McCormick, JL ;

McKee, TC ;

Cardellina, JH ;

Boyd, MR .

JOURNAL OF NATURAL PRODUCTS, 1996, 59 (05) :469-471

[10] FEASIBILITY OF A HIGH-FLUX ANTICANCER DRUG SCREEN USING A DIVERSE PANEL OF CULTURED HUMAN TUMOR-CELL LINES [J].

MONKS, A ;

SCUDIERO, D ;

SKEHAN, P ;

SHOEMAKER, R ;

PAULL, K ;

VISTICA, D ;

HOSE, C ;

LANGLEY, J ;

CRONISE, P ;

VAIGROWOLFF, A ;

GRAYGOODRICH, M ;

CAMPBELL, H ;

MAYO, J ;

BOYD, M .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1991, 83 (11) :757-766

← 1 2 →