Treatment of Cutaneous Calciphylaxis with Sodium Thiosulfate Two Case Reports and a Review of the Literature

被引：24

作者：

Auriemma, Matteo ^{[1
]}

Carbone, Angelo ^{[1
,2
]}

Di Liberato, Lorenzo ^{[3
]}

Cupaiolo, Antonietta ^{[1
]}

Caponio, Chiara ^{[1
]}

De Simone, Clara ^{[2
]}

Tulli, Antonio ^{[1
]}

Bonomini, Mario ^{[3
]}

Amerio, Paolo ^{[1
]}

机构：

[1] Univ G dAnnunzio, Dept Dermatol, I-66013 Chieti, Italy

[2] Univ Cattolica Sacro Cuore, Dept Dermatol, Rome, Italy

[3] Univ G dAnnunzio, Dept Nephrol, I-66013 Chieti, Italy

来源：

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY | 2011年 / 12卷 / 05期

关键词：

CALCIFIC UREMIC ARTERIOLOPATHY; STAGE RENAL-DISEASE; HEMODIALYSIS-PATIENT; HYDROGEN-SULFIDE; PATHOGENESIS; HYPERPARATHYROIDISM; MANAGEMENT; CINACALCET; RESOLUTION;

D O I：

10.2165/11587060-000000000-00000

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

Cutaneous calciphylaxis is a potentially fatal condition characterized by calcium deposition in dermal arterioles and the subsequent development of livedo reticularis, plaques, and extremely painful ulcers. This condition may be present in up to 4% of end-stage renal disease patients. Several treatments, which mainly attempt to control calcium phosphate metabolism, are available for this condition. We describe two patients treated with sodium thiosulfate with good results. Moreover, we also performed a PubMed literature search of sodium thiosulfate treatment for calciphylaxis. We found 41 cases of which most (> 90%) presented a rapid and sustained resolution, indicating this drug is a very good candidate for the treatment of this condition.

引用

页码：339 / 346

页数：8

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