Molecular Insight into Dengue Virus Pathogenesis and Its Implications for Disease Control

被引：211

作者：

Diamond, Michael S. ^{[1
,2
,3
]}

Pierson, Theodore C. ^{[4
]}

机构：

[1] Washington Univ, Sch Med, Ctr Human Immunol & Immunotherapy Programs, Dept Med, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Ctr Human Immunol & Immunotherapy Programs, Dept Mol Microbiol, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Ctr Human Immunol & Immunotherapy Programs, Dept Pathol & Immunol, St Louis, MO 63110 USA

[4] NIAID, Viral Pathogenesis Sect, NIH, Bethesda, MD 20892 USA

来源：

CELL | 2015年 / 162卷 / 03期

关键词：

INFECTION; ENHANCEMENT; STABILITY; DYNAMICS; BIOLOGY; PROTEIN; IMPACT;

D O I：

10.1016/j.cell.2015.07.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dengue virus (DENV) is a mosquito-transmitted RNA virus that infects an estimated 390 million humans each year. Here, we review recent advances in our understanding of the biology of DENV and describe knowledge gaps that have impacted the development of effective vaccines and therapeutics.

引用

页码：488 / 492

页数：5

共 30 条

[1] DENV Inhibits Type I IFN Production in Infected Cells by Cleaving Human STING
Aguirre, Sebastian
Maestre, Ana M.
Pagni, Sarah
Patel, Jenish R.
Savage, Timothy
Gutman, Delia
Maringer, Kevin
Bernal-Rubio, Dabeiba
Shabman, Reed S.
Simon, Viviana
Rodriguez-Madoz, Juan R.
Mulder, Lubbertus C. F.
Barber, Glen N.
Fernandez-Sesma, Ana
[J]. PLOS PATHOGENS, 2012, 8 (10):
[2] [Anonymous], J INFECT DIS
[3] Mouse STAT2 Restricts Early Dengue Virus Replication
Ashour, Joseph
Morrison, Juliet
Laurent-Rolle, Maudry
Belicha-Villanueva, Alan
Plumlee, Courtney Ray
Bernal-Rubio, Dabeiba
Williams, Katherine L.
Harris, Eva
Fernandez-Sesma, Ana
Schindler, Christian
Garcia-Sastre, Adolfo
[J]. CELL HOST & MICROBE, 2010, 8 (05) : 410 - 421
[4] Lethal Antibody Enhancement of Dengue Disease in Mice Is Prevented by Fc Modification
Balsitis, Scott J.
Williams, Katherine L.
Lachica, Ruben
Flores, Diana
Kyle, Jennifer L.
Mehlhop, Erin
Johnson, Syd
Diamond, Michael S.
Beatty, P. Robert
Harris, Eva
[J]. PLOS PATHOGENS, 2010, 6 (02)
[5] The global distribution and burden of dengue
Bhatt, Samir
Gething, Peter W.
Brady, Oliver J.
Messina, Jane P.
Farlow, Andrew W.
Moyes, Catherine L.
Drake, John M.
Brownstein, John S.
Hoen, Anne G.
Sankoh, Osman
Myers, Monica F.
George, Dylan B.
Jaenisch, Thomas
Wint, G. R. William
Simmons, Cameron P.
Scott, Thomas W.
Farrar, Jeremy J.
Hay, Simon I.
[J]. NATURE, 2013, 496 (7446) : 504 - 507
[6] Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions
de Alwis, Ruklanthi
Smith, Scott A.
Olivarez, Nicholas P.
Messer, William B.
Huynh, Jeremy P.
Wahala, Wahala M. P. B.
White, Laura J.
Diamond, Michael S.
Baric, Ralph S.
Crowe, James E., Jr.
de Silva, Aravinda M.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (19) : 7439 - 7444
[7] Modeling the impact on virus transmission of Wolbachia-mediated blocking of dengue virus infection of Aedes aegypti
Ferguson, Neil M.
Duong Thi Hue Kien
Clapham, Hannah
Aguas, Ricardo
Vu Tuan Trung
Tran Nguyen Bich Chau
Popovici, Jean
Ryan, Peter A.
O'Neill, Scott L.
McGraw, Elizabeth A.
Vo Thi Long
Le Thi Dui
Nguyen, Hoa L.
Nguyen Van Vinh Chau
Wills, Bridget
Simmons, Cameron P.
[J]. SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (279)
[8] A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins
Fibriansah, Guntur
Tan, Joanne L.
Smith, Scott A.
de Alwis, Ruklanthi
Ng, Thiam-Seng
Kostyuchenko, Victor A.
Jadi, Ramesh S.
Kukkaro, Petra
de Silva, Aravinda M.
Crowe, James E.
Lok, Shee-Mei
[J]. NATURE COMMUNICATIONS, 2015, 6
[9] Fitness Impact and Stability of a Transgene Conferring Resistance to Dengue-2 Virus following Introgression into a Genetically Diverse Aedes aegypti Strain
Franz, Alexander W. E.
Sanchez-Vargas, Irma
Raban, Robyn R.
Black, William C.
James, Anthony A.
Olson, Ken E.
[J]. PLOS NEGLECTED TROPICAL DISEASES, 2014, 8 (05):
[10] George SL., 2015, J Infect Dis

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