Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction

被引：719

作者：

Kreek, MJ ^{[1
]}

Nielsen, DA ^{[1
]}

Butelman, ER ^{[1
]}

LaForge, KS ^{[1
]}

机构：

[1] Rockefeller Univ, Lab Biol Addict Dis, New York, NY 10021 USA

来源：

NATURE NEUROSCIENCE | 2005年 / 8卷 / 11期

关键词：

D O I：

10.1038/nn1583

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Genetic variation may partially underlie complex personality and physiological traits-such as impulsivity, risk taking and stress responsivity-as well as a substantial proportion of vulnerability to addictive diseases. Furthermore, personality and physiological traits themselves may differentially affect the various stages of addiction, defined chronologically as initiation of drug use, regular drug use, addiction/dependence and potentially relapse. Here we focus on recent approaches to the study of genetic variation in these personality and physiological traits, and their influence on and interaction with addictive diseases.

引用

页码：1450 / 1457

页数：8

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