Novel N-(phosphonomethyl) glycine derivatives:: Design, characterization and biological activity

被引：39

作者：

Naydenova, Emilia D. ^{[2
]}

Todorov, Petar T. ^{[2
]}

Topashka-Ancheva, Margarita N. ^{[3
]}

Momekov, Georgi Ts. ^{[4
]}

Yordanova, Tsvetelina Z. ^{[3
]}

Konstantinov, Spiro M. ^{[4
]}

Troev, Kolio D. ^{[1
]}

机构：

[1] Bulgarian Acad Sci, Inst Polymers, BU-1113 Sofia, Bulgaria

[2] Univ Chem Technol & Met, Dept Organ Chem, BU-1756 Sofia, Bulgaria

[3] Bulgarian Acad Sci, Inst Zool, Sofia 1000, Bulgaria

[4] Med Univ Sofia, Lab Expt Chemotherapy, Dept Pharmacol Pharmacotherapy & Toxicol, Fac Pharm, Sofia 1000, Bulgaria

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2008年 / 43卷 / 06期

关键词：

aminophosphonic acids; N-(phosphonomethyl) glycine derivatives; chromosome aberrations; cell proliferation; clastogenic effects; cytotoxic activity;

D O I：

10.1016/j.ejmech.2007.08.010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of C alpha,alpha-disubstituted cyclic derivatives of N-(phosphonomethyl) glycine have been synthesized and characterized. They exhibited moderate clastogenicity, low antiproliferative activity on mice bone marrow cells and well expressed cytotoxicity against human tumor cell lines. The 8- and 12-membered cyclic analogs proved superior to the remaining compounds and were found to trigger apoptotic cell death in DOHH-2 cells. The latter compound caused 50% inhibition of the viability of hemobastose-derived cell lines at concentrations ranging from 20 to 67 mu M. (c) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：1199 / 1205

页数：7

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