Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 Outbreak

被引：1203

作者：

Dai, Mengyuan ^{[1
,2
,3
]}

Liu, Dianbo ^{[4
,5
]}

Liu, Miao ^{[6
]}

Zhou, Fuxiang ^{[2
,3
,7
]}

Li, Guiling ^{[8
]}

Chen, Zhen ^{[9
]}

Zhang, Zhian ^{[10
]}

You, Hua ^{[11
]}

Wu, Meng ^{[12
]}

Zheng, Qichao ^{[12
]}

Xiong, Yong ^{[13
]}

Xiong, Huihua ^{[14
]}

Wang, Chun ^{[15
]}

Chen, Changchun ^{[16
]}

Xiong, Fei ^{[17
]}

Zhang, Yan ^{[18
]}

Peng, Yaqin ^{[18
]}

Ge, Siping ^{[19
]}

Zhen, Bo ^{[20
]}

Yu, Tingting ^{[21
]}

Wang, Ling ^{[22
]}

Wang, Hua ^{[23
]}

Liu, Yu ^{[2
,3
,7
]}

Chen, Yeshan ^{[8
]}

Mei, Junhua ^{[10
]}

Gao, Xiaojia ^{[15
]}

Li, Zhuyan ^{[24
]}

Gan, Lijuan ^{[1
,2
,3
]}

He, Can ^{[1
,2
,3
]}

Li, Zhen ^{[1
,2
,3
]}

Shi, Yuying ^{[1
,2
,3
]}

Qi, Yuwen ^{[1
,2
,3
]}

Yang, Jing ^{[1
,2
,3
]}

Tenen, Daniel G. ^{[25
,26
]}

Chai, Li ^{[6
]}

Mucci, Lorelei A. ^{[27
]}

Santillana, Mauricio ^{[4
,5
]}

Cai, Hongbing ^{[1
,2
,3
,28
]}

机构：

[1] Wuhan Univ, Dept Gynecol Oncol, Zhongnan Hosp, Wuhan, Hubei, Peoples R China

[2] Hubei Key Lab Tumor Biol Behav, Wuhan, Peoples R China

[3] Hubei Canc Clin Study Ctr, Wuhan, Peoples R China

[4] Boston Childrens Hosp, Computat Hlth Informat Program, Boston, MA USA

[5] Harvard Med Sch, Dept Pediat, Boston, MA 02115 USA

[6] Harvard Med Sch, Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[7] Wuhan Univ, Dept Oncol, Zhongnan Hosp, Wuhan, Hubei, Peoples R China

[8] Huazhong Univ Sci & Technol, Canc Ctr, Union Hosp, Tongji Med Coll, Wuhan, Hubei, Peoples R China

[9] Huazhong Univ Sci & Technol, Dept Emergency, Cent Hosp Wuhan, Tongji Med Coll, Wuhan, Hubei, Peoples R China

[10] Cent Hosp Huanggang, Dept Gynecol, Huanggang, Hubei, Peoples R China

[11] Guangzhou Med Univ, Affiliated Canc Hosp & Inst, Guangzhou, Guangdong, Peoples R China

[12] Wuhan Univ, Dept Ultrasound, Zhongnan Hosp, Wuhan, Peoples R China

[13] Wuhan Univ, Dept Infect Dis, Zhongnan Hosp, Wuhan, Peoples R China

[14] Huazhong Univ Sci & Technol, Canc Ctr, Tongji Hosp, Tongji Med Coll, Wuhan, Hubei, Peoples R China

[15] Huazhong Univ Sci & Technol, Dept Oncol, Cent Hosp Wuhan, Tongji Med Coll, Wuhan, Hubei, Peoples R China

[16] Hubei Canc Hosp, Dept Radiol, Wuhan, Hubei, Peoples R China

[17] Hubei Canc Hosp, Dept Thorac Surg, Wuhan, Hubei, Peoples R China

[18] Wuhan Univ, Dept Obstet & Gynecol, Renmin Hosp, Wuhan, Peoples R China

[19] Wuhan Puren Hosp, Dept Oncol, Wuhan, Hubei, Peoples R China

[20] Cent Hosp Xianning, Dept Obstet & Gynecol, Xianning, Hubei, Peoples R China

[21] Cent Hosp Xiaogan, Dept Oncol, Xiaogan, Peoples R China

[22] Peoples Hosp Huangmei, Dept Obstet & Gynecol, Huangmei, Hubei, Peoples R China

[23] Hubei Univ Med, Dept Obstet & Gynecol, Xiangyang Peoples Hosp 1, Xiangyang, Hubei, Peoples R China

[24] Peoples Hosp Shiyan, Dept Obstet & Gynecol, Shiyan, Hubei, Peoples R China

[25] Harvard Med Sch, Harvard Stem Cell Inst, Boston, MA 02115 USA

[26] Natl Univ Singapore, Canc Sci Inst Singapore, Singapore, Singapore

[27] Harvard TH Chan Sch Publ Hlth, Dana Farber, Harvard Canc Ctr, Boston, MA USA

[28] Wuhan Univ, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China

来源：

CANCER DISCOVERY | 2020年 / 10卷 / 06期

基金：

英国医学研究理事会; 中国国家自然科学基金;

关键词：

RISK;

D O I：

10.1158/2159-8290.CD-20-0422

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The novel COVID-19 outbreak has affected more than 200 countries and territories as of March 2020. Given that patients with cancer are generally more vulnerable to infections, systematic analysis of diverse cohorts of patients with cancer affected by COVID-19 is needed. We performed a multicenter study including 105 patients with cancer and 536 age-matched noncancer patients confirmed with COVID-19. Our results showed COVID-19 patients with cancer had higher risks in all severe outcomes. Patients with hematologic cancer, lung cancer, or with metastatic cancer (stage IV) had the highest frequency of severe events. Patients with nonmetastatic cancer experienced similar frequencies of severe conditions to those observed in patients without cancer. Patients who received surgery had higher risks of having severe events, whereas patients who underwent only radiotherapy did not demonstrate significant differences in severe events when compared with patients without cancer. These findings indicate that patients with cancer appear more vulnerable to SARS-CoV-2 outbreak. SIGNIFICANCE: Because this is the first large cohort study on this topic, our report will provide much-needed information that will benefit patients with cancer globally. As such, we believe it is extremely important that our study be disseminated widely to alert clinicians and patients.

引用

页码：783 / 791

页数：9

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