Safety and efficacy of pallidal or subthalamic nucleus stimulation in advanced PD

被引：315

作者：

Volkmann, J

Allert, N

Voges, J

Weiss, PH

Freund, HJ

Sturm, V

机构：

[1] Univ Dusseldorf, Dept Neurol, D-40225 Dusseldorf, Germany

[2] Forschungszentrum Julich, IME, Julich, Germany

[3] Univ Cologne, Dept Stereotaxy & Funct Neurosurg, Cologne, Germany

来源：

NEUROLOGY | 2001年 / 56卷 / 04期

关键词：

D O I：

10.1212/WNL.56.4.548

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors retrospectively compared 1-year results of bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN; n = 16) and internal pallidum (GPi) (n = 11) in advanced PD and found about equal improvements in "off" period motor symptoms, dyskinesias, and fluctuations. STN stimulation reduced medication requirements by 65% and required significantly less electrical power. These advantages contrasted with a need for more intensive postoperative monitoring and a higher incidence of adverse events related to levodopa withdrawal.

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页码：548 / 551

页数：4

相关论文

共 10 条

[1] Bilateral subthalamic stimulation for Parkinson's disease by using three-dimensional stereotactic magnetic resonance imaging and electrophysiological guidance [J].

Bejjani, BP ;

Dormont, D ;

Pidoux, B ;

Yelnik, J ;

Damier, P ;

Arnulf, I ;

Bonnet, AM ;

Marsault, C ;

Agid, Y ;

Philippon, J ;

Cornu, P .

JOURNAL OF NEUROSURGERY, 2000, 92 (04) :615-625

[2] Deep brain stimulation in Parkinson's disease: Opposite effects of stimulation in the pallidum [J].

Bejjani, BP ;

Damier, P ;

Papadopoulos, S ;

Bonnet, AM ;

Vidailhet, M ;

Agid, Y ;

Pidoux, B ;

Cornu, P ;

Dormont, D ;

Marsault, C .

MOVEMENT DISORDERS, 1998, 13 (06) :969-970

[3]

Burchiel KJ, 1999, NEUROSURGERY, V45, P1375, DOI 10.1097/00006123-199912000-00024

[4] PRIMATE MODELS OF MOVEMENT-DISORDERS OF BASAL GANGLIA ORIGIN [J].

DELONG, MR .

TRENDS IN NEUROSCIENCES, 1990, 13 (07) :281-285

[5] Subthalamic stimulation in Parkinson disease -: A multidisciplinary approach [J].

Houeto, JL ;

Damier, P ;

Bejjani, PB ;

Staedler, C ;

Bonnet, AM ;

Arnulf, I ;

Pidoux, B ;

Dormont, D ;

Cornu, P ;

Agid, Y .

ARCHIVES OF NEUROLOGY, 2000, 57 (04) :461-465

[6] Subthalamic nucleus or internal pallidal stimulation in young onset Parkinson's disease [J].

Krack, P ;

Pollak, P ;

Limousin, P ;

Hoffmann, D ;

Xie, J ;

Benazzouz, A ;

Benabid, AL .

BRAIN, 1998, 121 :451-457

[7] Opposite motor effects of pallidal stimulation in Parkinson's disease [J].

Krack, P ;

Pollak, P ;

Limousin, P ;

Hoffman, D ;

Benazzouz, A ;

Le Bas, JF ;

Koudsie, A ;

Benabid, AL .

ANNALS OF NEUROLOGY, 1998, 43 (02) :180-192

[8] Chronic subthalamic nucleus stimulation reduces medication requirements in Parkinson's disease [J].

Moro, E ;

Scerrati, M ;

Romito, LMA ;

Roselli, R ;

Tonali, P ;

Albanese, A .

NEUROLOGY, 1999, 53 (01) :85-90

[9] Pallidal stimulation: an alternative to pallidotomy? [J].

Tronnier, VM ;

Fogel, W ;

Kronenbuerger, M ;

Steinvorth, S .

JOURNAL OF NEUROSURGERY, 1997, 87 (05) :700-705

[10] Bilateral high-frequency stimulation of the internal globus pallidus in advanced Parkinson's disease [J].

Volkmann, J ;

Strum, V ;

Weiss, P ;

Kappler, J ;

Voges, J ;

Koulousakis, A ;

Lehrke, R ;

Hefter, H ;

Freund, HJ .

ANNALS OF NEUROLOGY, 1998, 44 (06) :953-961