Enamel structure properties controlled by engineered proteins in transgenic mice

被引：35

作者：

Fong, H

White, SN

Paine, ML

Luo, W

Snead, ML

Sarikaya, M ^{[1
]}

机构：

[1] Univ Washington, Dept Mat Sci & Engn, Seattle, WA 98195 USA

[2] Univ Calif Los Angeles, Sch Dent, Los Angeles, CA 90024 USA

[3] Univ So Calif, Sch Dent, Ctr Craniofacial Mol Biol, Los Angeles, CA 90089 USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2003年 / 18卷 / 11期

关键词：

amelogenin; dental enamel; nanoindentation; mechanical properties; transgenic mouse; nanohardness; elastic modulus;

D O I：

10.1359/jbmr.2003.18.11.2052

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Amelogenin protein has regulatory effects on enamel biofabrication in mammalian tooth. Using teeth obtained from transgenic mice that express two separate protein-engineered versions of amelogenins, we made structure-nanomechanical properties correlations and showed 21% hardness and 24% elastic modulus degradation compared with the age-matched wildtype littermates. We attribute the inferior properties to the disorganization of the protein matrix resulting in defective mineral formation.

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页码：2052 / 2059

页数：8

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