Basophils, IgE, and Autoantibody-Mediated Kidney Disease

被引：17

作者：

Bosch, Xavier ^{[1
]}

Lozano, Francisco ^{[2
]}

Cervera, Ricard ^{[3
]}

Ramos-Casals, Manuel ^{[3
]}

Min, Booki ^{[4
]}

机构：

[1] Univ Barcelona, Dept Internal Med, Hosp Clin, Inst Invest Bimoed August Pi i Sunyer, E-08036 Barcelona, Spain

[2] Univ Barcelona, Dept Immunol, Hosp Clin, Inst Invest Bimoed August Pi i Sunyer, E-08036 Barcelona, Spain

[3] Univ Barcelona, Dept Autoimmune Dis, Hosp Clin, Inst Invest Bimoed August Pi i Sunyer, E-08036 Barcelona, Spain

[4] Cleveland Clin Fdn, Dept Immunol, Lerner Res Inst, Cleveland, OH 44195 USA

来源：

JOURNAL OF IMMUNOLOGY | 2011年 / 186卷 / 11期

基金：

美国国家卫生研究院;

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; SPLENIC NON-B; IN-VIVO; IL-4; PRODUCTION; MAST-CELLS; T-CELL; TH2; IMMUNITY; RHEUMATOID-ARTHRITIS; AMBLYOMMA-AMERICANUM; ALLERGIC RESPONSES;

D O I：

10.4049/jimmunol.1002648

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Basophils are of interest in immunology due to their ability to produce a Th2-signature cytokine, IL-4, following activation. A new understanding of the role of basophils in immunity shows novel functions at a cellular level through which basophils influence adaptive immunity. This review summarizes new advances in basophil biology and discusses new roles for basophils in human disease, especially in the mediation of the pathogenesis of lupus nephritis. Recently, basophils have been shown to contribute to self-reactive Ab production in systemic lupus erythematosus and may enhance preexisting loss of B cell tolerance, suggesting that basophils, IL-4, and IgE mediate the pathogenesis of lupus nephritis by promoting the Th2 environment and activating autoreactive B cells. In addition to envisaging exciting therapeutic prospects, these novel findings open the way for the study of basophils in other autoimmune and renal diseases. The Journal of Immunology, 2011, 186: 6083-6090.

引用

页码：6083 / 6090

页数：8

共 85 条

[1]

Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis [J].