A role for extracellular metallothioneins in CNS injury and repair

被引：79

作者：

Chung, RS ^{[1
]}

West, AK ^{[1
]}

机构：

[1] Univ Tasmania, Sch Med, NeuroRepair Grp, Hobart, Tas 7001, Australia

来源：

NEUROSCIENCE | 2004年 / 123卷 / 03期

关键词：

astrocyte; brain injury; cytokine; inflammatory response; regeneration;

D O I：

10.1016/j.neuroscience.2003.10.019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

For many years, research focus on metallothioneins, small zinc binding proteins found predominantly within astrocytes in the brain, has centred on their ability to indirectly protect neurons from oxygen free radicals and heavy metal-induced neurotoxicity. However, in recent years it has been demonstrated that these proteins have previously unsuspected roles within the cellular response to brain injury. The aim of this commentary is to provide an overview of the exciting recent experimental evidence from several laboratories including our own suggesting a possible extracellular role for these proteins, and to present a hypothetical model explaining the newly identified function of extracellular metallothioneins in CNS injury and repair. (C) 2003 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：595 / 599

页数：5

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