Adrenomedullin and proadrenomudullin N-terminal 20 peptide (PAMP) are present in human colonic epithelia and exert an antimicrobial effect

被引：39

作者：

Marutsuka, M

Nawa, Y

Asada, Y ^{[1
]}

Hara, S

Kitamura, K

Eto, T

Sumiyoshi, A

机构：

[1] Miyazaki Med Coll, Dept Pathol 1, Miyazaki 88916, Japan

[2] Miyazaki Med Coll, Dept Parasitol, Miyazaki 88916, Japan

[3] Miyazaki Med Coll, Dept Internal Med 1, Miyazaki 88916, Japan

来源：

EXPERIMENTAL PHYSIOLOGY | 2001年 / 86卷 / 05期

关键词：

D O I：

10.1113/eph8602250

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The hypotensive and vasorelaxing peptides adrenomedullin (AM) and its gene-related peptide, proadrenomedullin N-terminal 20 peptide (PAW), were found to be distributed on the surface of the colonic mucosa. AM and PAMP showed dose-dependent antimicrobial activity against E coli. The results suggest that the novel vasoactive peptides AM and PAMP play an important role in mucosal defence.

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收藏

页码：543 / 545

页数：3

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