Heart specific expression of mouse BMP-10 a novel member of the TGF-β superfamily

被引：133

作者：

Neuhaus, H ^{[1
]}

Rosen, V ^{[1
]}

Thies, RS ^{[1
]}

机构：

[1] Genet Inst Inc, Cambridge, MA 02140 USA

来源：

MECHANISMS OF DEVELOPMENT | 1999年 / 80卷 / 02期

关键词：

bone morphogenetic proteins; heart; BMP-10; trabeculation;

D O I：

10.1016/S0925-4773(98)00221-4

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Here we report the cloning and expression of murine BMP-10, a novel member of the TGF-beta superfamily. In the mouse embryo, BMP-10 expression begins at 9.0 d.p.c. and is restricted to the developing heart. Initially, BMP-10 expression localizes to the trabeculated part of the common ventricular chamber and to the bulbus cordis region. After 12.5 d.p.c., additional BMP-10 expression is seen in the atrial wall. The data presented here suggest that BMP-10 plays an important role in trabeculation of the embryonic heart. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：181 / 184

页数：4

共 7 条

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