Looking for trouble: A search for developmental defects of the hypothalamus

被引：35

作者：

Caqueret, A ^{[1
]}

Yang, C ^{[1
]}

Duplan, S ^{[1
]}

Boucher, F ^{[1
]}

Michaud, JL ^{[1
]}

机构：

[1] Hop St Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada

来源：

HORMONE RESEARCH | 2005年 / 64卷 / 05期

关键词：

hypothalamus; developmental defects; transcription factor; imprinting; energy balance;

D O I：

10.1159/000088977

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

The hypothalamus is a critical integrator of several homeostatic processes that are required for the survival of vertebrates. Disruption of the development of the hypothalamus thus has the potential of perturbing important physiological processes with lifelong consequences. We review current knowledge about how cell types are specified and circuits are formed within the developing hypothalamus. We emphasize the potential clinical impact of the perturbations of these pathways using the regulation of energy balance as a model. We predict that disruption of hypothalamic development is a common, previously unsuspected cause of disorders of homeostatic processes such as obesity and high blood pressure. Copyright (C) 2005 S. Karger AG, Basel.

引用

页码：222 / 230

页数：9

共 73 条

[1]

Progressive impairment of developing neuroendocrine cell lineages in the hypothalamus of mice lacking the Orthopedia gene [J].

Acampora, D ;

Postiglione, MP ;

Avantaggiato, V ;

Di Bonito, M ;

Vaccarino, FM ;

Michaud, J ;

Simeone, A .

GENES & DEVELOPMENT, 1999, 13 (21) :2787-2800

[2]

DISTRIBUTION OF PARTHENOGENETIC CELLS IN THE MOUSE-BRAIN AND THEIR INFLUENCE ON BRAIN-DEVELOPMENT AND BEHAVIOR [J].

ALLEN, ND ;

LOGAN, K ;

LALLY, G ;

DRAGE, DJ ;

NORRIS, ML ;

KEVERNE, EB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (23) :10782-10786

[3]

Expression of the Prader-Willi gene Necdin during mouse nervous system development correlates with neuronal differentiation and p75NTR expression [J].

Andrieu, D ;

Watrin, F ;

Niinobe, M ;

Yoshikawa, K ;

Muscatelli, F ;

Fernandez, PA .

GENE EXPRESSION PATTERNS, 2003, 3 (06) :761-765

[4]

Stressed-out, or in (utero)? [J].

Avishai-Eliner, S ;

Brunson, KL ;

Sandman, CA ;

Baram, TZ .

TRENDS IN NEUROSCIENCES, 2002, 25 (10) :518-524

[5]

EFFECTS OF INTRACEREBROVENTRICULAR INJECTION OF NEUROPEPTIDE-Y ON ENERGY-METABOLISM [J].

BILLINGTON, CJ ;

BRIGGS, JE ;

GRACE, M ;

LEVINE, AS .

AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 260 (02) :R321-R327

[6]

Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size [J].

Blevins, JE ;

Schwartz, MW ;

Baskin, DG .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2004, 287 (01) :R87-R96

[7]

Trophic action of leptin on hypothalamic neurons that regulate feeding [J].

Bouret, SG ;

Draper, SJ ;

Simerly, RB .

SCIENCE, 2004, 304 (5667) :108-110

[8]

Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice [J].

Bouret, SG ;

Draper, SJ ;

Simerly, RB .

JOURNAL OF NEUROSCIENCE, 2004, 24 (11) :2797-2805

[9]

Translating developmental time across mammalian species [J].

Clancy, B ;

Darlington, RB ;

Finlay, BL .

NEUROSCIENCE, 2001, 105 (01) :7-17

[10]

Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: Evidence of a cellular basis for the adipostat [J].

Cowley, MA ;

Pronchuk, N ;

Fan, W ;

Dinulescu, DM ;

Colmers, WF ;

Cone, RD .

NEURON, 1999, 24 (01) :155-163

← 1 2 3 4 5 6 7 8 →