Effects of prenatal exposure to toluene on postnatal development and behavior in rats

被引：57

作者：

Hougaard, KS ^{[1
]}

Hass, U ^{[1
]}

Lund, SP ^{[1
]}

Simonsen, L ^{[1
]}

机构：

[1] Natl Inst Occupat Hlth, Dept Chem Working Environm, DK-2100 Copenhagen O, Denmark

来源：

NEUROTOXICOLOGY AND TERATOLOGY | 1999年 / 21卷 / 03期

关键词：

toluene; CAS-no; 108-88-3; inhalation; prenatal exposure; neurobehavioral toxicity; rats; Morris water maze;

D O I：

10.1016/S0892-0362(98)00053-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Development and neurobehavioral effects of prenatal exposure to toluene (CAS 108-88-3) were studied after exposing pregnant rats (Mol:WIST) to 1800 ppm of the solvent for 6 h daily on days 7-20 of gestation. Body weights of exposed offspring were lower until day 10 after parturition. Neurobehavioral evaluation of the pups revealed no effects on motor function (rotarod), activity level (open field), acoustic startle, and prepulse inhibition. Measurements of hearing function using auditory brain stem response revealed small effects in male-exposed offspring. Performance in a Morris water maze during initial learning gave some indications of impaired cognitive functions, which was confirmed during further testing, especially in reversal and new learning. Effects on cognitive functions seemed most marked in female offspring. (C) 1999 Elsevier Science Inc. All rights reserved.

引用

页码：241 / 250

页数：10

共 51 条

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