MicroRNA regulation of lymphocyte tolerance and autoimmunity

被引：120

作者：

Simpson, Laura J. ^{[1
]}

Ansel, K. Mark ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Microbiol & Immunol, Sandler Asthma Basic Res Ctr, San Francisco, CA 94143 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2015年 / 125卷 / 06期

基金：

美国国家科学基金会;

关键词：

CD4(+) T-CELLS; MULTIPLE-SCLEROSIS; CUTTING EDGE; B-CELLS; MIR-17-SIMILAR-TO-92; FAMILY; TH17; DIFFERENTIATION; MEDIATED REGULATION; NEGATIVE REGULATION; MIRNA EXPRESSION; FOXP3; EXPRESSION;

D O I：

10.1172/JCI78090

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Understanding the cell-intrinsic cues that permit self-reactivity in lymphocytes, and therefore autoimmunity, requires an understanding of the transcriptional and posttranscriptional regulation of gene expression in these cells. In this Review, we address seminal and recent research on microRNA (mIRNA) regulation of central and peripheral tolerance. Human and mouse studies demonstrate that the PI3K pathway is a critical point of miRNA regulation of immune cell development and function that affects the development of autoimmunity. We also discuss how miRNA expression profiling in human autoimmune diseases has inspired mechanistic studies of miRNA function in the pathogenesis of multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes, and asthma.

引用

收藏

页码：2242 / 2249

页数：8

相关论文

共 95 条

[1]

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b [J].

Bachmaier, K ;

Krawczyk, C ;

Kozieradzki, I ;

Kong, YY ;

Sasaki, T ;

Oliveira-dos-Santos, A ;

Mariathasan, S ;

Bouchard, D ;

Wakeham, A ;

Itie, A ;

Le, J ;

Ohashi, PS ;

Sarosi, I ;

Nishina, H ;

Lipkowitz, S ;

Penninger, JM .

NATURE, 2000, 403 (6766) :211-216

[2]

Banham-Hall Edward, 2012, Open Rheumatol J, V6, P245, DOI 10.2174/1874312901206010245

[3]

MicroRNAs: Target Recognition and Regulatory Functions [J].

Bartel, David P. .

CELL, 2009, 136 (02) :215-233

[4]

MicroRNA-mediated regulation of T helper cell differentiation and plasticity [J].

Baumjohann, Dirk ;

Ansel, K. Mark .

NATURE REVIEWS IMMUNOLOGY, 2013, 13 (09) :666-678

[5]

The microRNA cluster miR-17∼92 promotes TFH cell differentiation and represses subset-inappropriate gene expression [J].

Baumjohann, Dirk ;

Kageyama, Robin ;

Clingan, Jonathan M. ;

Morar, Malika M. ;

Patel, Sana ;

de Kouchkovsky, Dimitri ;

Bannard, Oliver ;

Bluestone, Jeffrey A. ;

Matloubian, Mehrdad ;

Ansel, K. Mark ;

Jeker, Lukas T. .

NATURE IMMUNOLOGY, 2013, 14 (08) :840-+

[6]

MicroRNAs Prevent the Generation of Autoreactive Antibodies [J].

Belver, Laura ;

de Yebenes, Virginia G. ;

Ramiro, Almudena R. .

IMMUNITY, 2010, 33 (05) :713-722

[7]

The type 1 diabetes resistance locus B10 Idd9.3 mediates impaired B-cell lymphopoiesis and implicates microRNA-34a in diabetes protection [J].

Berry, Gregory J. ;

Budgeon, Lynn R. ;

Cooper, Timothy K. ;

Christensen, Neil D. ;

Waldner, Hanspeter .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2014, 44 (06) :1716-1727

[8]

Essential Role of MicroRNA-155 in the Pathogenesis of Autoimmune Arthritis in Mice [J].

Blueml, Stephan ;

Bonelli, Michael ;

Niederreiter, Birgit ;

Puchner, Antonia ;

Mayr, Georg ;

Hayer, Silvia ;

Koenders, Marije I. ;

van den Berg, Wim B. ;

Smolen, Josef ;

Redlich, Kurt .

ARTHRITIS AND RHEUMATISM, 2011, 63 (05) :1281-1288

[9]

Borlado LR, 2000, FASEB J, V14, P895

[10]

Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity [J].

Bryniarski, Krzysztof ;

Ptak, Wlodzimierz ;

Jayakumar, Asha ;

Puellmann, Kerstin ;

Caplan, Michael J. ;

Chairoungdua, Arthit ;

Lu, Jun ;

Adams, Brian D. ;

Sikora, Emilia ;

Nazimek, Katarzyna ;

Marquez, Susanna ;

Kleinstein, Steven H. ;

Sangwung, Panjamaporn ;

Iwakiri, Yasuko ;

Delgato, Eric ;

Redegeld, Frank ;

Blokhuis, Bart R. ;

Wojcikowski, Jacek ;

Daniel, Wladyslawa Anna ;

Kormelink, Tom Groot ;

Askenase, Philip W. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2013, 132 (01) :170-+

← 1 2 3 4 5 6 7 8 9 10 →