Acne phototherapy using U.V free high intensity narrow band blue light - 3 center clinical study.

被引：19

作者：

Shalita, AR ^{[1
]}

Harth, Y ^{[1
]}

Elman, M ^{[1
]}

Slatkine, M ^{[1
]}

Talpalariu, G ^{[1
]}

Rosenberg, Y ^{[1
]}

Korman, A ^{[1
]}

Klein, A ^{[1
]}

机构：

[1] Suny Downstate Med Ctr, Brooklyn, NY 11203 USA

来源：

LASERS IN SURGERY: ADVANCED CHARACTERIZATION THERAPEUTICS, AND SYSTEMS XI | 2001年 / 4244卷

关键词：

acne; p.acnes; inflammatory acne; narrow band; blue light; porphyrins; phototoxic; phototherapy; acne photoclearing;

D O I：

10.1117/12.427830

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Propionibacterium. acnes is a Gram positive, microaerophilic bacterium which takes a part in the pathogenesis of inflammatory acne. P. acnes is capable to produce high amounts endogenic porphyrins with no need of any trigger molecules. Light in the violet-blue range (407-420 nn) has been shown to exhibit a phototoxic effect on Propionibacterium acnes when irradiated in vitro. The purpose of our study was to test the clinical effects of a high intensity narrowband blue light source on papulo pustular acne. A total of 35 patients in 3 centers were treated twice a week with a high intensity metal halide lamp illuminating the entire face (20x20 cm2) or the back with visible light in the 407-420 nm range at an intensity of 90mW/cm(2) (CureLight Ltd.) for a total of 4 weeks. UV is totally cut off. In each treatment the patient was exposed to light for 8-15 minutes. After 8 treatments, 80% of the patients with mild to moderate papulo-pustular acne showed significant improvement at reducing the numbers of non-inflammatory, inflammatory and total facial lesions. Inflammatory lesion count decrease by a mean of 68%. No side effects to the treatment were noticed. In conclusion, full face or back illumination with the high intensity pure blue light we used exhibits a rapid significant decrees in acne lesions counts in 8 biweekly treatments.

引用

页码：61 / 73

页数：13

共 13 条

[1]

ASHKENAZI H, 2000, P 24 ANN M ISR SOC D

[2] THE MICROAEROPHILY AND PHOTOSENSITIVITY OF PROPIONIBACTERIUM-ACNES [J].