Carboxymethyl tamarind kernel polysaccharide nanoparticles for ophthalmic drug delivery

被引：83

作者：

Kaur, Harmanmeet ^{[1
]}

Ahuja, Munish ^{[2
]}

Kumar, Sandeep ^{[1
]}

Dilbaghi, Neeraj ^{[1
]}

机构：

[1] Guru Jambheshwar Univ Sci & Technol, Dept Bio & Nano Technol, Nanomat Synth & Characterizat Lab, Hisar 125001, Haryana, India

[2] Guru Jambheshwar Univ Sci & Technol, Dept Pharmaceut Sci, Drug Delivery Res Lab, Hisar 125001, Haryana, India

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2012年 / 50卷 / 03期

关键词：

Carboxymethyl tamarind kernel powder; Tropicamide; Ionotropic gelation; Nanoparticles; Corneal permeation; CHORIOALLANTOIC MEMBRANE; PHARMACOKINETICS; SAFETY;

D O I：

10.1016/j.ijbiomac.2011.11.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Tropicamide-loaded carboxymethyl tamarind kernel polysaccharide (CMTKP) nanoparticles were prepared and evaluated for ocular delivery. Preparation of ionotropically gelled CMTKP nanoparticles was optimized employing three-levels, two-factor central composite design. Concentration of polymer and crosslinker had significant synergistic effect on particle size and % encapsulation efficiency. The optimal calculated parameters were concentrations of CMTKP 0.10% (w/v) and calcium chloride 0.11% (w/v). The optimized tropicamide-loaded CMTKP formulation showed ex vivo corneal permeation of tropicamide across isolated goat cornea comparable to its aqueous solution. Further, the mucoadhesive and non-irritant nature of CMTKP nanoparticles indicate their suitability as ocular delivery system. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：833 / 839

页数：7

共 38 条

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