Development of nevirapine resistance in infants is reduced by use of infant-only single-dose nevirapine plus zidovudine postexposure prophylaxis for the prevention of mother-to-child transmission of HIV-1

被引：35

作者：

Eshleman, SH

Hoover, DR

Hudelson, SE

Chen, S

Fiscus, SA

Piwowar-Manning, E

Jackson, JB

Kumwenda, NI

Taha, TE

机构：

[1] Johns Hopkins Univ, Baltimore, MD 21218 USA

[2] Rutgers State Univ, Piscataway, NJ USA

[3] Univ N Carolina, Chapel Hill, NC 27515 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2006年 / 193卷 / 04期

关键词：

D O I：

10.1086/499967

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We analyzed the development of nevirapine ( NVP) resistance in human immunodeficiency virus type 1 ( HIV-1)-infected Malawian infants who received regimens containing singledose NVP ( SD-NVP) for the prevention of mother-to-child transmission ( MTCT) of HIV-1. All infants received SD- NVP, and some randomly received zidovudine ( ZDV) as well. Mothers did or did not receive SD- NVP on the basis of when they arrived at the hospital for delivery. In infants 6 - 8 weeks of age, NVP resistance was less frequent when infants had received SD- NVP plus ZDV and mothers had not received SD- NVP than when infants had received SD- NVP alone and mothers had received SD- NVP ( 4/15 [ 27%] vs. 20/23 [ 87%]; P < .001). The risk of MTCT of HIV- 1 was comparable with these regimens. Infant-only prophylaxis also eliminates the development of NVP resistance in mothers.

引用

页码：479 / 481

页数：3

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