Semisynthetic dimers of antiparkinsonic ergot alkaloids

被引：5

作者：

Kren, V ^{[1
]}

Weignerová, L ^{[1
]}

Kuzma, M ^{[1
]}

Jegorov, A ^{[1
]}

Sedmera, P ^{[1
]}

机构：

[1] Acad Sci Czech Republ, Inst Microbiol, Lab Biotransformat, CZ-14220 Prague 4, Czech Republic

来源：

HETEROCYCLES | 2001年 / 55卷 / 06期

关键词：

D O I：

10.3987/COM-01-9180

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,1-Linked dimers of semisynthetic ergoline alkaloids with antiparkinsonic activity were prepared in 60 - 63% yield from the parent compounds (pergolide, terguride) by action of alpha,omega -dihalogenalkanes in DMSO/KOH. N-1-omega -Halogenalkyl pergolide and terguride precursors were used for the synthesis of non-symmetric dimers. N-6 Alkylation was achieved (yield 18 - 28%) using 1,6-dihalogenohexane in DMF/K2CO3.

引用

页码：1045 / 1056

页数：12

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