Injectable and Cytocompatible Tough Double-Network Hydrogels through Tandem Supramolecular and Covalent Crosslinking

被引：314

作者：

Rodell, Christopher B. ^{[1
]}

Dusaj, Neville N. ^{[1
]}

Highley, Christopher B. ^{[1
]}

Burdick, Jason A. ^{[1
]}

机构：

[1] Univ Penn, Dept Bioengn, 210 South 33rd St, Philadelphia, PA 19104 USA

来源：

ADVANCED MATERIALS | 2016年 / 28卷 / 38期

基金：

美国国家卫生研究院;

关键词：

biomaterials; double networks; supramolecular chemistry; tissue engineering; HYALURONIC-ACID HYDROGELS; BIOMEDICAL APPLICATIONS; POLY(ETHYLENE GLYCOL); PERFORMANCE; CHEMISTRY; STRENGTH; FRACTURE; AGAROSE; GELS;

D O I：

10.1002/adma.201602268

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Double-network theory is extended to include guest-host interactions, enabling injectability and cytcompatibility of tough hydrogels. Noncovalent interactions are used as a sacrificial network to toughen covalently crosslinked hydrogels formed from hyaluronic acid. Shear thinning of supramolecular bonds allows hydrogel injection and rapid self-healing, while gentle reaction conditions permit cell encapsulation with high viability.

引用

页码：8419 / 8424

页数：6

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