Curcumin derivatives as new ligands of Aβ peptides

被引：38

作者：

Airoldi, Cristina ^{[1
]}

Zona, Cristiano ^{[1
]}

Sironi, Erika ^{[1
]}

Colombo, Laura ^{[2
]}

Messa, Massimo ^{[2
]}

Aurilia, Dario ^{[1
]}

Gregori, Maria ^{[3
]}

Masserini, Massimo ^{[3
]}

Salmona, Mario ^{[2
]}

Nicotra, Francesco ^{[1
]}

La Ferla, Barbara ^{[1
]}

机构：

[1] Univ Milano Bicocca, Dept Biotechnol & Biosci, I-20126 Milan, Italy

[2] Mario Negri Inst Pharmacol Res, Dept Mol Biochem & Pharmacol, I-20156 Milan, Italy

[3] Univ Milano Bicocca, Dept Expt Med, I-20052 Monza, MB, Italy

来源：

JOURNAL OF BIOTECHNOLOGY | 2011年 / 156卷 / 04期

关键词：

Alzheimer's disease; A beta peptides; A beta ligands; Curcumin derivatives; NMR interaction studies; Conformational analysis; Brain amyloid plaque staining; ALZHEIMERS-DISEASE; MOLECULAR-MECHANICS; NMR-SPECTROSCOPY; AQUEOUS-SOLUTION; PROTEIN; AGGREGATION; DEGRADATION; DRUGS; MOUSE; ONSET;

D O I：

10.1016/j.jbiotec.2011.07.021

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Curcumin derivatives with high chemical stability, improved solubility and carrying a functionalized appendage for the linkage to other entities, have been synthesized in a straightforward manner. All compounds retained Curcumin ability to bind A beta peptide oligomers without inducing their aggregation. Moreover all Curcumin derivatives were able to stain very efficiently A beta deposits. (C) 2011 Elsevier B. V. All rights reserved.

引用

页码：317 / 324

页数：8

共 40 条

[1] Tetracycline prevents Aβ oligomer toxicity through an atypical supramolecular interaction [J].