Proinflammatory responses in the murine brain after intranasal delivery of cholera toxin: Implications for the use of AB toxins as adjuvants in intranasal vaccines

被引：40

作者：

Armstrong, ME

Lavelle, EC

Loscher, CE

Lynch, MA

Mills, KHG ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Sch Biochem & Immunol, Immune Regulat Res Grp, Dublin 2, Ireland

[2] Univ Dublin Trinity Coll, Dept Physiol, Dublin 2, Ireland

[3] Univ Dublin Trinity Coll, Inst Neurosci, Dublin 2, Ireland

来源：

JOURNAL OF INFECTIOUS DISEASES | 2005年 / 192卷 / 09期

基金：

爱尔兰科学基金会;

关键词：

D O I：

10.1086/491739

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Intranasal delivery of vaccines provides an attractive alternative to parenteral delivery, but it requires appropriate mucosal adjuvants. Cholera toxin (CT) is a powerful mucosal adjuvant, but it can undergo retrograde transport to the brain via the olfactory system after intranasal delivery. We demonstrate that intranasal delivery of CT increases the expression of interleukin-1 beta, cyclooxygenase-2, and chemokine messenger RNA in the murine hypothalamus, whereas parenterally delivered CT has little effect. Our findings suggest that CT can induce proinflammatory mediators in the brain when it is administered intranasally but not parenterally, and they raise concerns about the use of AB toxins as adjuvants in intranasal vaccines.

引用

收藏

页码：1628 / 1633

页数：6

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