The herpesvirus Saimiri ORF50 gene, encoding a transcriptional activator homologous to the Epstein-Barr virus R protein, is transcribed from two distinct promoters of different temporal phases

被引:54
作者
Whitehouse, A [1 ]
Carr, IM [1 ]
Griffiths, JC [1 ]
Meredith, DM [1 ]
机构
[1] UNIV LEEDS,ST JAMES HOSP,MOL MED UNIT,LEEDS LS9 7TF,W YORKSHIRE,ENGLAND
基金
英国惠康基金;
关键词
D O I
10.1128/JVI.71.3.2550-2554.1997
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The mRNA species encoding the herpesvirus saimiri (HVS) homolog of the Epstein-Barr virus R transcriptional activator (termed ORF50) have been identified and used to determine transcriptional start sites within the gene. The first transcript is spliced and starts from a promoter within ORF49 containing a single intron; the second is produced from a promoter within the second exon and is in the same reading frame. The spliced transcript is detected at early times during productive virus replication in OMK cells, whereas the nonspliced transcript is detected later. The spliced transcript is fivefold-more potent in activating the delayed-early ORF6 promoter; the function of the nonspliced transcript is unclear. Thus, the role of this protein in activating herpesvirus saimiri from the latent state may differ significantly from that of the Epstein-Barr virus R protein.
引用
收藏
页码:2550 / 2554
页数:5
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