Treatment with captopril abrogates the altered expression of alpha1 macroglobulin and alpha1 antiproteinase in sera of spontaneously hypertensive rats

被引：3

作者：

Aminudin, Norhaniza ^{[1
,2
]}

Abdullah, Nur-Atiqah H. ^{[1
]}

Misbah, Hasni ^{[3
]}

Karsani, Saiful A. ^{[1
,2
]}

Husain, Ruby ^{[4
]}

Hoe, See Z. ^{[4
]}

Hashim, Onn H. ^{[2
,3
]}

机构：

[1] Univ Malaya, Inst Biol Sci, Fac Sci, Kuala Lumpur 50603, Malaysia

[2] Univ Malaya, Ctr Prote Res, Kuala Lumpur 50603, Malaysia

[3] Univ Malaya, Dept Mol Med, Fac Med, Kuala Lumpur 50603, Malaysia

[4] Univ Malaya, Dept Physiol, Fac Med, Kuala Lumpur 50603, Malaysia

来源：

PROTEOME SCIENCE | 2012年 / 10卷

关键词：

hypertension; biomarker; spontaneously hypertensive rats; serum proteins; proteomics; RETINOL-BINDING PROTEIN-4; TONIN; INHIBITOR;

D O I：

10.1186/1477-5956-10-17

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

Background: Proteins that are associated with hypertension may be identified by comparing the 2-dimensional gel electrophoresis (2-DE) profiles of the sera of spontaneously hypertensive rats (SHR) with those generated from normotensive Spraque-Dawley rats (SDR). Results: Five proteins of high abundance were found to be significantly altered when the 2-DE serum profiles of the SHR were compared to those that were similarly generated from the SDR. Analysis by mass spectrometry and database search identified the proteins as retinol binding protein 4, complement C3, albumin (19.9 kDa fragment), alpha1 macroglobulin and alpha1 antiproteinase, which are all known to be associated with hypertension. The altered expression of the two latter proteins was found to be abrogated when similar analysis was performed on sera of the SHR that were treated with captopril. Conclusion: Our data suggests that serum alpha1 macroglobulin and alpha1 antiproteinase are potentially useful complementary biomolecular indicators for monitoring of hypertension.

引用

页数：7

共 24 条

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