Interaction of S-SCAM with neural plakophilin-related armadillo-repeat protein/δ-catenin

被引：73

作者：

Ide, N

Hata, Y

Deguchi, M

Hirao, K

Yao, I

Takai, Y

机构：

[1] Osaka Univ, Sch Med, Dept Mol Biol & Biochem, Suita, Osaka 5650871, Japan

[2] JCR Pharmacuet Co Ltd, Takai Biotimer Project, ERATO, Japan Sci & Technol Corp, Kobe, Hyogo 6512241, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1999年 / 256卷 / 03期

关键词：

D O I：

10.1006/bbrc.1999.0364

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Synaptic scaffolding molecule (S-SCAM) is a multiple PDZ domain-containing protein, which interacts with neuroligin, a cell adhesion molecule, and the NMDA receptor. In this study, we searched for S-SCAM-interacting proteins and obtained a neural plakophilin-related armadillo-repeat protein (NPRAP)/delta-catenin, NPRAP/delta-catenin bound to the last PDZ domain of S-SCAM via its carboxyl-terminus in three different cell-free assay systems, was coimmunoprecipitated with S-SCAM from rat crude synaptosomes, and was localized at the excitatory synapses in rat hippocampal neurons. NPRAP/delta-catenin may be implicated in the molecular organization of synaptic junctions through the interaction with S-SCAM, (C) 1999 Academic Press.

引用

页码：456 / 461

页数：6

共 24 条

[1] Requirement for the PDZ domain protein, INAD, for localization of the TRP store-operated channel to a signaling complex [J].