Merging structural biology with chemical biology: Structural Chemistry at Eskitis

被引：8

作者：

Hofmann, Andreas ^{[1
]}

Wang, Conan K. ^{[1
]}

Osman, Asiah ^{[1
]}

Camp, David ^{[2
]}

机构：

[1] Griffith Univ, Struct Chem Program, Eskitis Inst Cell & Mol Therapies, Nathan, Qld 4111, Australia

[2] Griffith Univ, Queensland Compound Lib, Eskitis Inst Cell & Mol Therapies, Nathan, Qld 4111, Australia

来源：

STRUCTURAL CHEMISTRY | 2010年 / 21卷 / 05期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

Molecular mechanisms; Protein crystallography; Protein structure-function; Rational drug design; NEURONAL CALCIUM SENSOR-1; BOUND CRYSTAL-STRUCTURES; N-TERMINAL PEPTIDES; WD-REPEAT; ANNEXIN I; NATURAL-PRODUCTS; PROTEIN; MEMBRANE; DIVERSITY; MECHANISM;

D O I：

10.1007/s11224-010-9654-2

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This review introduces the Structural Chemistry Program at Griffith University's Eskitis Institute, and provides a brief overview over its current and future research portfolio. Capitalising on the co-location with the Queensland Compound Library (QCL), Australia's only small molecule repository, our laboratory investigates the structure and function of proteins with the aim of learning about their molecular mechanisms. Consequently, these studies also feed into drug discovery and design. The thematic focus of our Program is on proteins involved in infection, inflammation and neurological diseases, and this review highlights a few of our recent research efforts in this area.

引用

页码：1117 / 1129

页数：13

共 99 条

[1]

[Anonymous], 2002, PYMOL MOL GRAPHICS S

[2]

[Anonymous], 2007, DRUG DISCOV WORLD

[3] The crystal structure of murine coronin-1: A regulator of actin cytoskeletal dynamics in lymphocytes [J].

Appleton, BA ;

Wu, P ;

Wiesmann, C .

STRUCTURE, 2006, 14 (01) :87-96

[4] X-ray structure of Na-ASP-2, a pathogenesis-related-1 protein from the nematode parasite, Necator americanus, and a vaccine antigen for human hookworm infection [J].

Asojo, OA ;

Goud, G ;

Dhar, K ;

Loukas, A ;

Zhan, B ;

Deumic, V ;

Liu, S ;

Borgstahl, GEO ;

Hotez, PJ .

JOURNAL OF MOLECULAR BIOLOGY, 2005, 346 (03) :801-814

[5] IL1 receptor accessory protein like, a protein involved in X-linked mental retardation, interacts with Neuronal Calcium Sensor-1 and regulates exocytosis [J].

Bahi, N ;

Friocourt, G ;

Carrié, A ;

Graham, ME ;

Weiss, JL ;

Chafey, P ;

Fauchereau, F ;

Burgoyne, RD ;

Chelly, J .

HUMAN MOLECULAR GENETICS, 2003, 12 (12) :1415-1425

[6] The structure and mechanism of protein phosphatases: Insights into catalysis and regulation [J].

Barford, D ;

Das, AK ;

Egloff, MP .

ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 1998, 27 :133-164

[7] New anthelmintics for livestock: the dime is right [J].

Besier, Brown .

TRENDS IN PARASITOLOGY, 2007, 23 (01) :21-24

[8] Mechanism of annexin I-mediated membrane aggregation [J].

Bitto, E ;

Li, M ;

Tikhonov, AM ;

Schlossman, ML ;

Cho, W .

BIOCHEMISTRY, 2000, 39 (44) :13469-13477

[9]

Bohacek RS, 1996, MED RES REV, V16, P3, DOI 10.1002/(SICI)1098-1128(199601)16:1<3::AID-MED1>3.0.CO

[10]

2-6

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