Modulation of voltage-dependent calcium channels by G proteins

被引：162

作者：

Zamponi, GW ^{[1
]}

Snutch, TP

机构：

[1] Univ Calgary, Dept Pharmacol & Therapeut, Calgary, AB T2N 4N1, Canada

[2] Univ British Columbia, Biotechnol Lab, Vancouver, BC V6T 1Z3, Canada

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1998年 / 8卷 / 03期

关键词：

D O I：

10.1016/S0959-4388(98)80060-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Voltage-gated calcium channels are found in all excitable cells, in which they regulate many important physiological functions, including excitability, gene transcription, muscle contraction, and neurotransmitter and hormone release. The differential modulation of calcium channels by intracellular second messengers constitutes a key mechanism for controlling calcium influx. Recent advances have provided important clues to the underlying molecular mechanisms involved in the inhibition of N-type and P/Q-type calcium channels by a membrane-delimited G-protein-dependent pathway.

引用

页码：351 / 356

页数：6

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