Biodegradable electrospun fibers for drug delivery

被引：736

作者：

Jing, Z ^{[1
]}

Xu, XY ^{[1
]}

Chen, XS ^{[1
]}

Liang, QZ ^{[1
]}

Bian, XC ^{[1
]}

Yang, LX ^{[1
]}

Jing, XB ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China

来源：

JOURNAL OF CONTROLLED RELEASE | 2003年 / 92卷 / 03期

基金：

中国国家自然科学基金;

关键词：

drug delivery; electrospinning; ultrafine fibers;

D O I：

10.1016/S0168-3659(03)00372-9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The influences of surfactants and medical drugs on the diameter size and uniformity of electrospun poly(L-lactic acid) (PLLA) fibers were examined by adding various surfactants (cationic, anionic, and nonionic) and typical drugs into the PLLA solution. Significant diameter reduction and uniformity improvement were observed. It was shown that the drugs were capsulated inside of the fibers and the drug release in the presence of proteinase K followed nearly zero-order kinetics due to the degradation of the PLLA fibers. Such ultrafine fiber mats containing drugs may find clinical applications in the future. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：227 / 231

页数：5

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