Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts

被引：50

作者：

Chiu, Po Yee ^{[1
]}

Lam, Philip Y. ^{[1
]}

Yan, Chung Wai ^{[1
]}

Ko, Kam Ming ^{[1
]}

机构：

[1] Hong Kong Univ Sci & Technol, Dept Biochem, Hong Kong, Hong Kong, Peoples R China

来源：

FITOTERAPIA | 2011年 / 82卷 / 04期

关键词：

Schisandrin B; Solar irradiation; Photo-aging; Oxidative stress; Glutathione; BJ human fibroblasts; ISCHEMIA-REPERFUSION INJURY; RAT HEARTS; STRUCTURAL DETERMINANTS; ELASTASE ACTIVITY; UV-IRRADIATION; HUMAN SKIN; GLUTATHIONE; METALLOPROTEINASES; EXPRESSION; MECHANISM;

D O I：

10.1016/j.fitote.2011.02.010

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

The effects of schisandrin B (Sch B) and its analogs on solar irradiation-induced oxidative injury were examined in BJ human fibroblasts. Sch B and schisandrin C (Sch C) increased cellular reduced glutathione (GSH) level and protected against solar irradiation-induced oxidative injury. The photoprotection was paralleled by decreases in the elastases-type protease activity and matrix-metalloproteinases-1 expression in solar-irradiated fibroblasts. The cytochrome P-450-mediated metabolism of Sch B or Sch C caused ROS production. The results suggest that by virtue of its pro-oxidant action and the subsequent glutathione antioxidant response, Sch B or Sch C may offer the prospect of preventing skin photo-aging. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：682 / 691

页数：10

共 29 条

[1]

POTENTIAL INVOLVEMENT OF FREE-RADICAL REACTIONS IN ULTRAVIOLET LIGHT-MEDIATED CUTANEOUS DAMAGE [J].

BLACK, HS .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1987, 46 (02) :213-221

[2]

Schisandrin B-Induced Glutathione Antioxidant Response and Cardioprotection Are Mediated by Reactive Oxidant Species Production in Rat Hearts [J].

Chen, Na ;

Ko, Kam Ming .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2010, 33 (05) :825-829

[3]

Schisandrin B protects myocardial ischemia-reperfusion injury partly by inducing Hsp25 and Hsp70 expression in rats [J].

Chiu, PY ;

Ko, KM .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2004, 266 (1-2) :139-144

[4]

CHIU PY, MOL CELL BIOCH

[5]

DETERMINATION OF GLUTATHIONE AND GLUTATHIONE DISULFIDE USING GLUTATHIONE-REDUCTASE AND 2-VINYLPYRIDINE [J].

GRIFFITH, OW .

ANALYTICAL BIOCHEMISTRY, 1980, 106 (01) :207-212

[6]

Mechanism of UVB-Induced Wrinkling of the Skin: Paracrine Cytokine Linkage between Keratinocytes and Fibroblasts Leading to the Stimulation of Elastase [J].

Imokawa, Genji .

JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS, 2009, 14 (01) :36-43

[7]

EFFECT OF SCHISANDRIN-B ON HEPATIC GLUTATHIONE ANTIOXIDANT SYSTEM IN MICE - PROTECTION AGAINST CARBON-TETRACHLORIDE TOXICITY [J].

IP, SP ;

POON, MKT ;

WU, SS ;

CHE, CT ;

NG, KH ;

KONG, YC ;

KO, KM .

PLANTA MEDICA, 1995, 61 (05) :398-401

[8]

Recent advances in characterizing biological mechanisms underlying UV-induced wrinkles: a pivotal role of fibrobrast-derived elastase [J].

Irnokawa, Genji .

ARCHIVES OF DERMATOLOGICAL RESEARCH, 2008, 300 (Suppl 1) :S7-S20

[9]

RETRACTED: Structural determinants of schisandrin B which enhance mitochondrial functional ability and glutathione status as well as heat shock protein expression in rat hearts and H9c2 cells (Retracted Article) [J].

Ko, KM ;

Chiu, PY .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2005, 276 (1-2) :227-234

[10]

Schisandrin B protects against tert-butylhydroperoxide induced cerebral toxicity by enhancing glutathione antioxidant status in mouse brain [J].

Ko, KM ;

Lam, BYH .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2002, 238 (1-2) :181-186

← 1 2 3 →