Neural basis for verb processing in Alzheimer's disease: An fMRI study

被引:28
作者
Grossman, M
Koenig, P
DeVita, C
Glosser, G
Moore, P
Gee, J
Detre, J
Alsop, D
机构
[1] Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Dept Radiol, Philadelphia, PA 19104 USA
[3] Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USA
关键词
D O I
10.1037/0894-4105.17.4.658
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Patients with probable Alzheimer's disease (AD) have difficulty understanding verbs. To investigate the neural basis for this deficit, the authors used functional magnetic resonance imaging to examine patterns of neural activation during verb processing in I I AD patients compared with 16 healthy seniors. Subjects judged the pleasantness of verbs, including MOTION verbs and COGNITION verbs. Healthy seniors and AD patients both activated posterolateral temporal and inferior frontal regions during judgments of verbs. These activations were relatively reduced and somewhat changed in their anatomic distribution in AD patients compared with healthy seniors, particularly for the subcategory of MOTION verbs, but AD patients showed minimal activation in association with COGNITION verbs. These findings imply that poor performance with verbs in AD is due in part to altered activation of the large-scale neural network that supports verb processing.
引用
收藏
页码:658 / 674
页数:17
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