Clinical trial of acetazolamide in SCA6, with assessment using the Ataxia Rating Scale and body stabilometry

被引：47

作者：

Yabe, I

Sasaki, H

Yamashita, I

Takei, A

Tashiro, K

机构：

[1] Hokkaido Univ, Sch Med, Dept Neurol, Kita Ku, Sapporo, Hokkaido 0608638, Japan

[2] Hokuyukai Neurol Hosp, Sapporo, Hokkaido 0630802, Japan

来源：

ACTA NEUROLOGICA SCANDINAVICA | 2001年 / 104卷 / 01期

关键词：

acetazolamide; spinocerebellar ataxia type 6 (SCA6); ataxia rating scale; stabilometer;

D O I：

10.1034/j.1600-0404.2001.00299.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective - To investigate the effect of acetazolamide on spinocerebellar ataxia type 6 (SCA6). Methods - Acetazolamide (250-500 mg/day) was administered orally for 88 weeks to 6 patients with SCA6, and its effect was quantitatively monitored using the Ataxia Rating Scale (ARS) and body sway analysis by stabilometry. Results - During administration of acetazolamide, the ARS score and the amplitude of body sway were significantly reduced compared with before administration. However, the response became weaker after 1 year of treatment. Conclusion - Although this was an open trial, the results suggested that acetazolamide can temporarily reduce the severity of symptoms during the progression of SCA6.

引用

页码：44 / 47

页数：4

共 10 条

[1] Posterior vermal split syndrome [J].

Bastian, AJ ;

Mink, JW ;

Kaufman, BA ;

Thach, WT .

ANNALS OF NEUROLOGY, 1998, 44 (04) :601-610

[2] High prevalence of CACNA1A truncations and broader clinical spectrum in episodic ataxia type 2 [J].

Denier, C ;

Ducros, A ;

Vahedi, K ;

Joutel, A ;

Thierry, P ;

Ritz, A ;

Castelnovo, G ;

Deonna, T ;

Gérard, P ;

Devoize, JL ;

Gayou, A ;

Perrouty, B ;

Soisson, T ;

Autret, A ;

Warter, JM ;

Vighetto, A ;

Van Bogaert, P ;

Alamowitch, S ;

Roullet, E ;

Tournier-Lasserve, E .

NEUROLOGY, 1999, 52 (09) :1816-1821

[3] HEREDITARY PAROXYSMAL ATAXIA - RESPONSE TO ACETAZOLAMIDE [J].

GRIGGS, RC ;

MOXLEY, RT ;

LAFRANCE, RA ;

MCQUILLEN, J .

NEUROLOGY, 1978, 28 (12) :1259-1264

[4] Spinocerebellar ataxia type 6 with positional vertigo and acetazolamide responsive episodic ataxia [J].

Jen, JC ;

Yue, Q ;

Karrim, J ;

Nelson, SF ;

Baloh, RW .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1998, 65 (04) :565-568

[5] Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4 [J].

Ophoff, RA ;

Terwindt, GM ;

Vergouwe, MN ;

vanEijk, R ;

Oefner, PJ ;

Hoffman, SMG ;

Lamerdin, JE ;

Mohrenweiser, HW ;

Bulman, DE ;

Ferrari, M ;

Haan, J ;

Lindhout, D ;

vanOmmen, GJB ;

Hofker, MH ;

Ferrari, MD ;

Frants, RR .

CELL, 1996, 87 (03) :543-552

[6] CEREBELLAR CONNECTIONS WITH THE MOTOR CORTEX AND THE ARCUATE PREMOTOR AREA - AN ANALYSIS EMPLOYING RETROGRADE TRANS-NEURONAL TRANSPORT OF WGA-HRP [J].

ORIOLI, PJ ;

STRICK, PL .

JOURNAL OF COMPARATIVE NEUROLOGY, 1989, 288 (04) :612-626

[7] International Cooperative Ataxia Rating Scale for pharmacological assessment of the cerebellar syndrome [J].

Trouillas, P ;

Takayanagi, T ;

Hallett, M ;

Currier, RD ;

Subramony, SH ;

Wessel, K ;

Bryer, A ;

Diener, HC ;

Massaquoi, S ;

Gomez, CM ;

Coutinho, P ;

BenHamida, M ;

Campanella, G ;

Filla, A ;

Schut, L ;

Timann, D ;

Honnorat, J ;

Nighoghossian, N ;

Manyam, B .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1997, 145 (02) :205-211

[8]

Yabe I, 1999, Rinsho Shinkeigaku, V39, P793

[9] SCA6 mutation analysis in a large cohort of the Japanese patients with late-onset pure cerebellar ataxia [J].

Yabe, I ;

Sasaki, H ;

Matsuura, T ;

Takada, A ;

Wakisaka, A ;

Suzuki, Y ;

Fukazawa, T ;

Hamada, T ;

Oda, T ;

Ohnishi, A ;

Tashiro, K .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1998, 156 (01) :89-95

[10]

ZHUNCHENKO O, 1997, NAT GENET, V15, P62

← 1 →