Osteoprotegerin: a link between osteoporosis and arterial calcification?

被引：138

作者：

Hofbauer, LC ^{[1
]}

Schoppet, M

机构：

[1] Univ Marburg, Dept Med, Div Gastroenterol & Endocrinol, D-35033 Marburg, Germany

[2] Univ Marburg, Dept Med, Div Cardiol, D-35033 Marburg, Germany

来源：

LANCET | 2001年 / 358卷 / 9278期

关键词：

D O I：

10.1016/S0140-6736(01)05494-0

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

引用

收藏

页码：257 / 259

页数：3

相关论文

共 16 条

[1]

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function [J].

Anderson, DM ;

Maraskovsky, E ;

Billingsley, WL ;

Dougall, WC ;

Tometsko, ME ;

Roux, ER ;

Teepe, MC ;

DuBose, RF ;

Cosman, D ;

Galibert, L .

NATURE, 1997, 390 (6656) :175-179

[2]

The effect of a single dose of osteoprotegerin in postmenopausal women [J].

Bekker, PJ ;

Holloway, D ;

Nakanishi, A ;

Arrighi, M ;

Leese, PT ;

Dunstan, CR .

JOURNAL OF BONE AND MINERAL RESEARCH, 2001, 16 (02) :348-360

[3]

Associations of serum osteoprotegerin levels with diabetes, stroke, bone density, fractures, and mortality in elderly women [J].

Browner, WS ;

Lui, LY ;

Cummings, SR .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (02) :631-637

[4]

osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification [J].

Bucay, N ;

Sarosi, I ;

Dunstan, CR ;

Morony, S ;

Tarpley, J ;

Capparelli, C ;

Scully, S ;

Tan, HL ;

Xu, WL ;

Lacey, DL ;

Boyle, WJ ;

Simonet, WS .

GENES & DEVELOPMENT, 1998, 12 (09) :1260-1268

[5]

Progression of aortic calcification is associated with metacarpal bone loss during menopause - A population-based longitudinal study [J].

Hak, AE ;

Pols, HAP ;

van Hemert, AM ;

Hofman, A ;

Witteman, JCM .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (08) :1926-1931

[6]

Effects of immunosuppressants on receptor activator of NF-κB ligand and osteoprotegerin production by human osteoblastic and coronary artery smooth muscle cells [J].

Hofbauer, LC ;

Shui, CX ;

Riggs, BL ;

Dunstan, CR ;

Spelsberg, TC ;

O'Brien, T ;

Khosla, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 280 (01) :334-339

[7]

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand [J].

Kong, YY ;

Feïge, U ;

Sarosi, I ;

Bolon, B ;

Tafuri, A ;

Morony, S ;

Capparelli, C ;

Li, J ;

Elliott, R ;

McCabe, S ;

Wong, T ;

Campagnuolo, G ;

Moran, E ;

Bogoch, ER ;

Van, G ;

Nguyen, LT ;

Ohashi, PS ;

Lacey, DL ;

Fish, E ;

Boyle, WJ ;

Penninger, JM .

NATURE, 1999, 402 (6759) :304-309

[8]

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis [J].

Kong, YY ;

Yoshida, H ;

Sarosi, I ;

Tan, HL ;

Timms, E ;

Capparelli, C ;

Morony, S ;

Oliveira-dos-Santos, AJ ;

Van, G ;

Itie, A ;

Khoo, W ;

Wakeham, A ;

Dunstan, CR ;

Lacey, DL ;

Mak, TW ;

Boyle, WJ ;

Penninger, JM .

NATURE, 1999, 397 (6717) :315-323

[9]

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation [J].

Lacey, DL ;

Timms, E ;

Tan, HL ;

Kelley, MJ ;

Dunstan, CR ;

Burgess, T ;

Elliott, R ;

Colombero, A ;

Elliott, G ;

Scully, S ;

Hsu, H ;

Sullivan, J ;

Hawkins, N ;

Davy, E ;

Capparelli, C ;

Eli, A ;

Qian, YX ;

Kaufman, S ;

Sarosi, I ;

Shalhoub, V ;

Senaldi, G ;

Guo, J ;

Delaney, J ;

Boyle, WJ .

CELL, 1998, 93 (02) :165-176

[10]

Osteoprotegerin is an αvβ3-induced, NF-κB-dependent survival factor for endothelial cells [J].

Malyankar, UM ;

Scatena, M ;

Suchland, KL ;

Yun, TJ ;

Clark, EA ;

Giachelli, CM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (28) :20959-20962