Leucine sources for the rat fetus

被引：20

作者：

Beckman, DA ^{[1
]}

Brent, RL ^{[1
]}

Lloyd, JB ^{[1
]}

机构：

[1] THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,DIV DEV BIOL,PHILADELPHIA,PA 19107

来源：

PLACENTA | 1997年 / 18卷 / 01期

关键词：

D O I：

10.1016/S0143-4004(97)90074-6

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fetal and maternal plasma were assayed for the concentration of free leucine, acid-insoluble radioactivity and acid-soluble radioactivity at intervals after an intravenous bolus injection of [H-3]leucine into anaesthetized pregnant rats at 17.5 days post-conception. The concentrations of total free leucine and of free [H-3]leucine in maternal and fetal plasma were effectively unchanged from 5 to 180 min post-injection. Plasma free leucine concentrations in the fetus were five times those in the mother. The concentration of free [H-3]leucine in fetal plasma was similar to that in maternal plasma. Thus the specific radioactivity of free leucine in fetal plasma is substantially lower than that in maternal plasma, indicating that a significant portion of the free leucine in plasma of the 17.5-day rat fetus comes from a source other than the free leucine in the maternal plasma. The data are consistent with a major contribution of amino acids coming from the degradation of extraembryonic protein in the yolk sac. Other possible sources of unlabelled leucine are discussed. (C) 1997 W. B. Saunders Company Ltd.

引用

页码：79 / 82

页数：4

共 17 条

[1] EFFECTS OF 24 HOUR STARVATION ON PLASMA COMPOSITION IN 19 AND 21 DAY PREGNANT RATS AND THEIR FETUSES [J].

AROLA, L ;

PALOU, A ;

REMESAR, X ;

ALEMANY, M .

HORMONE AND METABOLIC RESEARCH, 1982, 14 (07) :364-371

[2]

BAKER HJ, 1980, LABORATORY RAT, V2, P257

[3]

Beckman D. A., 1995, Teratology, V51, P178

[4] PINOCYTOSIS IN THE RAT VISCERAL YOLK-SAC - POTENTIAL ROLE IN AMINO-ACID NUTRITION DURING THE FETAL PERIOD [J].

BECKMAN, DA ;

BRENT, RL ;

LLOYD, JB .

PLACENTA, 1994, 15 (02) :171-176

[5] SOURCES OF AMINO-ACIDS FOR PROTEIN-SYNTHESIS DURING EARLY ORGANOGENESIS IN THE RAT .1. RELATIVE CONTRIBUTIONS OF FREE AMINO-ACIDS AND OF PROTEINS [J].

BECKMAN, DA ;

PUGARELLI, JE ;

JENSEN, M ;

KOSZALKA, TR ;

BRENT, RL ;

LLOYD, JB .

PLACENTA, 1990, 11 (02) :109-121

[6] SOURCES OF AMINO-ACIDS FOR PROTEIN-SYNTHESIS DURING EARLY ORGANOGENESIS IN THE RAT .2. EXCHANGE WITH AMINO-ACID AND PROTEIN POOLS IN EMBRYO AND YOLK-SAC [J].

BECKMAN, DA ;

PUGARELLI, JE ;

KOSZALKA, TR ;

BRENT, RL ;

LLOYD, JB .

PLACENTA, 1991, 12 (01) :37-46

[7] Sources of amino acids for protein synthesis during early organogenesis in the rat .4. Mechanisms before envelopment of the embryo by the yolk sac [J].

Beckman, DA ;

Brent, RL ;

Lloyd, JB .

PLACENTA, 1996, 17 (08) :635-641

[8] DISTRIBUTION OF FREE AMINO-ACIDS IN STREPTOZOTOCIN-INDUCED DIABETIC PREGNANT RATS, THEIR PLACENTAE AND FETUSES [J].

COPELAND, AD ;

HENDRICH, CE ;

PORTERFIELD, SP .

HORMONE AND METABOLIC RESEARCH, 1990, 22 (02) :65-70

[9] PRESERVED FETAL PLASMA AMINO-ACID-CONCENTRATIONS IN THE PRESENCE OF MATERNAL HYPOAMINOACIDEMIA [J].

DOMENECH, M ;

GRUPPUSO, PA ;

NISHINO, VT ;

SUSA, JB ;

SCHWARTZ, R .

PEDIATRIC RESEARCH, 1986, 20 (11) :1071-1076

[10]

FREEMAN SJ, 1981, J EMBRYOL EXP MORPH, V66, P223

← 1 2 →