Enzymes for chemical synthesis

被引:723
作者
Koeller, KM
Wong, CH
机构
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
关键词
D O I
10.1038/35051706
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
New catalytic synthetic methods in organic chemistry that satisfy increasingly stringent environmental constraints are in great demand by the pharmaceutical and chemical industries. In addition, novel catalytic procedures are necessary to produce the emerging classes of organic compounds that are becoming the targets of molecular and biomedical research. Enzyme-catalysed chemical transformations are now widely recognized as practical alternatives to traditional (non-biological) organic synthesis, and as convenient solutions to certain intractable synthetic problems.
引用
收藏
页码:232 / 240
页数:9
相关论文
共 81 条
[1]   Design by directed evolution [J].
Arnold, FH .
ACCOUNTS OF CHEMICAL RESEARCH, 1998, 31 (03) :125-131
[2]   Bioorganic synthesis of lipid-modified proteins for the study of signal transduction [J].
Bader, B ;
Kuhn, K ;
Owen, DJ ;
Waldmann, H ;
Wittinghofer, A ;
Kuhlmann, J .
NATURE, 2000, 403 (6766) :223-226
[3]   Substrate mimetic mediated peptide synthesis: An irreversible ligation strategy that is independent of substrate specificity [J].
Bordusa, F ;
Ullmann, D ;
Elsner, C ;
Jakubke, HD .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1997, 36 (22) :2473-2475
[4]  
Burkart MD, 1999, ANGEW CHEM INT EDIT, V38, P2747, DOI 10.1002/(SICI)1521-3773(19990917)38:18<2747::AID-ANIE2747>3.0.CO
[5]  
2-2
[6]   The reaction cycle of isopenicillin N synthase observed by X-ray diffraction [J].
Burzlaff, NI ;
Rutledge, PJ ;
Clifton, IJ ;
Hensgens, CMH ;
Pickford, M ;
Adlington, RM ;
Roach, PL ;
Baldwin, JE .
NATURE, 1999, 401 (6754) :721-724
[7]   Biochemistry - Harnessing the biosynthetic code: Combinations, permutations, and mutations [J].
Cane, DE ;
Walsh, CT ;
Khosla, C .
SCIENCE, 1998, 282 (5386) :63-68
[8]  
Carrea G, 2000, ANGEW CHEM INT EDIT, V39, P2226
[9]   ENZYMATIC-SYNTHESIS OF HYALURONIC-ACID WITH REGENERATION OF SUGAR NUCLEOTIDES [J].
DELUCA, C ;
LANSING, M ;
MARTINI, I ;
CRESCENZI, F ;
SHEN, GJ ;
OREGAN, M ;
WONG, CH .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (21) :5869-5870
[10]  
Drauz K., 1995, ENZYME CATALYSIS ORG