Role of the thymus in pediatric HIV-1 infection

被引：40

作者：

Kirschner, DE

Mehr, R

Perelson, AS

机构：

[1] Univ Michigan, Sch Med, Dept Microbiol, Ann Arbor, MI USA

[2] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

[3] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM USA

来源：

JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 1998年 / 18卷 / 02期

关键词：

thymus; AIDS; ordinary differential equations; immunology; HIV; pediatric AIDS; mathematical modeling;

D O I：

10.1097/00042560-199806010-00001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Several lines of evidence suggest that HIV-1 is present in the thymus during HIV-1 infection. Precursors to mature CD4(+) T lymphocytes develop in the thymus, which suggests that thymic infection may play a role in the CD4(+) T-cell decline observed during the course of pediatric HIV-1 infection. We illustrate, through mathematical modeling, the potential effects of thymic infection on the course of pediatric AIDS disease progression. We find that infection in the thymus not only can supplement peripheral infection but can help explain the faster progression in pediatric cases, as well as the early and high viral burden.

引用

页码：95 / 109

页数：15

共 64 条

[1] Thymocyte and thymic microenvironment alterations during a systemic HIV infection in a severe combined immunodeficient mouse model [J].