Expression, extracellular secretion, and immunogenicity of the Plasmodium falciparum sporozoite surface protein 2 in Salmonella vaccine strains

被引：19

作者：

Gómez-Duarte, OG

Pasetti, MF

Santiago, A

Sztein, MB

Hoffman, SL

Levine, MM

机构：

[1] Univ Maryland, Sch Med, Dept Med, Ctr Vaccine Dev, Baltimore, MD 21201 USA

[2] Univ Nacl Autonoma Mexico, Inst Ciencias Biomed, Mexico City 04510, DF, Mexico

[3] USN, Malaria Program, Med Res Ctr, Rockville, MD 20852 USA

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 02期

关键词：

D O I：

10.1128/IAI.69.2.1192-1198.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Deleting transmembrane alpha -helix motifs from Plasmodium falciparum sporozoite surface protein (SSP-2) allowed its secretion from Salmonella enterica serovar Typhimurium SL3261 and S. enterica serovar Typhi CVD 908-htrA by the Hly type I secretion system. In mice immunized intranasally, serovar Typhimurium constructs secreting SSP-2 stimulated greater gamma interferon splenocyte responses than did nonsecreting constructs (P = 0.04).

引用

收藏

页码：1192 / 1198

页数：7

相关论文

共 43 条

[1] Expression and immunogenicity of pertussis toxin S1 subunit-tetanus toxin fragment C fusions in Salmonella typhi vaccine strain CVD 908 [J].

Barry, EM ;

GomezDuarte, O ;

Chatfield, S ;

Rappuoli, R ;

Pizza, M ;

Losonsky, G ;

Galen, J ;

Levine, MM .

INFECTION AND IMMUNITY, 1996, 64 (10) :4172-4181

[2] Development of two monoclonal antibodies against Plasmodium falciparum sporozoite surface protein 2 and mapping of B-cell epitopes [J].

Charoenvit, Y ;

Fallarme, V ;

Rogers, WO ;

Sacci, JB ;

Kaur, M ;

Aguiar, JC ;

Yuan, LF ;

Corradin, G ;

Andersen, E ;

Wizel, B ;

Houghten, RA ;

Oloo, A ;

DelaVega, P ;

Hoffman, SL .

INFECTION AND IMMUNITY, 1997, 65 (08) :3430-3437

[3] EVALUATION OF SALMONELLA-TYPHIMURIUM STRAINS HARBORING DEFINED MUTATIONS IN HTRA AND AROA IN THE MURINE SALMONELLOSIS MODEL [J].

CHATFIELD, SN ;

STRAHAN, K ;

PICKARD, D ;

CHARLES, IG ;

HORMAECHE, CE ;

DOUGAN, G .

MICROBIAL PATHOGENESIS, 1992, 12 (02) :145-151

[4] Prediction of transmembrane alpha-helices in prokaryotic membrane proteins: the dense alignment surface method [J].

Cserzo, M ;

Wallin, E ;

Simon, I ;

vonHeijne, G ;

Elofsson, A .

PROTEIN ENGINEERING, 1997, 10 (06) :673-676

[5] Oral somatic transgene vaccination using attenuated S-typhimurium [J].

Darji, A ;

Guzman, CA ;

Gerstel, B ;

Wachholz, P ;

Timmis, KN ;

Wehland, J ;

Chakraborty, T ;

Weiss, S .

CELL, 1997, 91 (06) :765-775

[6] The complexity of protective immunity against liver-stage malaria [J].

Doolan, DL ;

Hoffman, SL .

JOURNAL OF IMMUNOLOGY, 2000, 165 (03) :1453-1462

[7]

Doolan DL, 1999, J IMMUNOL, V163, P884

[8] Circumventing genetic restriction of protection against malaria with multigene DNA immunization: CD8(+) T cell-, interferon gamma-, and nitric oxide-dependent immunity [J].

Doolan, DL ;

Sedegah, M ;

Hedstrom, RC ;

Hobart, P ;

Charoenvit, Y ;

Hoffman, SL .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (04) :1739-1746

[9]

Galen JE, 1999, INFECT IMMUN, V67, P6424

[10] A murine model of intranasal immunization to assess the immunogenicity of attenuated Salmonella typhi live vector vaccines in stimulating serum antibody responses to expressed foreign antigens [J].

Galen, JE ;

GomezDuarte, OG ;

Losonsky, GA ;

Halpern, JL ;

Lauderbaugh, CS ;

Kaintuck, S ;

Reymann, MK ;

Levine, MM .

VACCINE, 1997, 15 (6-7) :700-708

← 1 2 3 4 5 →