Comparative role of antibiotic and proton pump inhibitor in experimental Clostridium difficile infection in mice

被引：34

作者：

Kaur, Sukhminderjit ^{[1
]}

Vaishnavi, Chetana ^{[1
]}

Prasad, Kaushal Kishore ^{[1
]}

Ray, Pallab ^{[2
]}

Kochhar, Rakesh ^{[1
]}

机构：

[1] Postgrad Inst Med Educ & Res, Dept Gastroenterol, Chandigarh 160012, India

[2] Postgrad Inst Med Educ & Res, Dept Med Microbiol, Chandigarh 160012, India

来源：

MICROBIOLOGY AND IMMUNOLOGY | 2007年 / 51卷 / 12期

关键词：

ampicillin; lansoprazole; Clostridium difficile;

D O I：

10.1111/j.1348-0421.2007.tb04016.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Clostridium difficile inoculated BALB/c mice were investigated to assess the comparative role of antibiotic and proton pump inhibitor. They were examined for colonization and toxin production by C. difficile as well as myeloperoxidase activity and histopathological changes in the intestinal tract. The C. difficile count, toxin A and B titres and myeloperoxidase activity were significantly higher (P>0.05) in ampicillin and lansoprazole receiving groups as compared to the control and the C. difficile receiving groups. Similarly they showed significant difference (P>0.05) for epithelial damage, oedema and neutrophilic infiltrate in colons. In addition to antibiotic, PPI also acts as an independent risk factor for C. difficile infection in experimental studies.

引用

页码：1209 / 1214

页数：6

共 21 条

[1] MEASUREMENT OF CUTANEOUS INFLAMMATION - ESTIMATION OF NEUTROPHIL CONTENT WITH AN ENZYME MARKER
BRADLEY, PP
PRIEBAT, DA
CHRISTENSEN, RD
ROTHSTEIN, G
[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1982, 78 (03) : 206 - 209
[2] PATHOGENICITY OF CLOSTRIDIUM SPECIES WITH OTHER BACTERIA IN MIXED INFECTIONS
BROOK, I
WALKER, RI
[J]. JOURNAL OF INFECTION, 1986, 13 (03) : 245 - 253
[3] Clostridium difficile-associated diarrhea and colitis -: Clinical manifestations, diagnosis and treatment
Cleary, RK
[J]. DISEASES OF THE COLON & RECTUM, 1998, 41 (11) : 1435 - 1449
[4] Use of gastric acid-suppressive agents and the risk of community-acquired Clostridium difficile-associated disease
Dial, S
Delaney, JAC
Barkun, AN
Suissa, S
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 294 (23): : 2989 - 2995
[5] Risk of Clostridium difficile diarrhea among hospital inpatients prescribed proton pump inhibitors:: cohort and case-control studies
Dial, S
Alrasadi, K
Manoukian, C
Huang, A
Menzies, D
[J]. CANADIAN MEDICAL ASSOCIATION JOURNAL, 2004, 171 (01) : 33 - 38
[6] The role of the intestinal tract as a reservoir and source for transmission of nosocomial pathogens
Donskey, CJ
[J]. CLINICAL INFECTIOUS DISEASES, 2004, 39 (02) : 219 - 226
[7] Fekety R, 1997, AM J GASTROENTEROL, V92, P739
[8] *IMS HLTH NAT SAL, 2004, YEAR END US PRESCR S
[9] Gastrin-mediated effects of omeprazole on rat colon mucosa
Klingensmith, ME
Neville, LJ
Delpire, E
Wolfe, MM
Soybel, DI
[J]. SURGERY, 1999, 126 (02) : 272 - 278
[10] QUANTITATIVE STUDY OF ANTIBIOTIC-INDUCED SUSCEPTIBILITY TO CLOSTRIDIUM-DIFFICILE ENTEROCECITIS IN HAMSTERS
LARSON, HE
BORRIELLO, SP
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (07) : 1348 - 1353

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