Natural killer cells and hepatitis C: action and reaction

被引：74

作者：

Cheent, Kuldeep ^{[1
]}

Khakoo, Salim I. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Div Med, London W2 1NS, England

来源：

GUT | 2011年 / 60卷 / 02期

基金：

英国惠康基金;

关键词：

B-VIRUS INFECTION; HUMAN NK CELLS; INHIBITORY RECEPTOR GENES; ADAPTIVE IMMUNE-RESPONSES; I-RELATED CHAIN; COMPLEX CLASS-I; HEPATOCELLULAR-CARCINOMA; INTERFERON-ALPHA; HLA-C; LIVER-TRANSPLANTATION;

D O I：

10.1136/gut.2010.212555

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In 1989, hepatitis C virus (HCV) was first identified as the infectious agent responsible for human non-A, non-B hepatitis.(1) Two decades later, HCV remains a global public health problem with a suboptimal response rate to treatment and the absence of a protective vaccine. Recent work has highlighted the influence of the innate immune system, and in particular natural killer cells, on the outcome and pathology of HCV infection. These cells are considerably more complex than was originally thought and their role in viral infections is currently being unravelled. This review summarises our emerging understanding of natural killer cells in HCV infection.

引用

页码：268 / 278

页数：11

共 107 条

[81] Adoptive transfer of TRAIL-expressing natural killer cells prevents recurrence of hepatocellular carcinoma after partial hepatectomy [J].

Ohira, Masahiro ;

Ohdan, Hideki ;

Mitsuta, Hiroshi ;

Ishiyama, Kohei ;

Tanaka, Yuka ;

Igarashi, Yuka ;

Asahara, Toshimasa .

TRANSPLANTATION, 2006, 82 (12) :1712-1719

[82] Natural Killer Cell Functional Dichotomy in Chronic Hepatitis B and Chronic Hepatitis C Virus Infections [J].

Oliviero, Barbara ;

Varchetta, Stefania ;

Paudice, Enrica ;

Michelone, Giuseppe ;

Zaramella, Marco ;

Mavilio, Domenico ;

De Filippi, Francesca ;

Bruno, Savino ;

Mondelli, Mario U. .

GASTROENTEROLOGY, 2009, 137 (03) :1151-1160

[83] Decrease in CD3-negative-CD8dim+ and Vδ2/Vγ9 TcR+ peripheral blood lymphocyte counts, low perforin expression and the impairment of natural killer cell activity is associated with chronic hepatitis C virus infection [J].

Pár, G ;

Rukavina, D ;

Podack, ER ;

Horányi, M ;

Szekeres-Barthó, J ;

Hegedüs, G ;

Paál, M ;

Szereday, L ;

Mózsik, G ;

Pár, A .

JOURNAL OF HEPATOLOGY, 2002, 37 (04) :514-522

[84] NK cells lose their inhibition [J].

Parham, P .

SCIENCE, 2004, 305 (5685) :786-787

[85] Increased degranulation of natural killer cells during acute HCV correlates with the magnitude of virus-specific T cell responses [J].

Pelletier, Sandy ;

Drouin, Christian ;

Bedard, Nathalie ;

Khakoo, Salim I. ;

Bruneau, Julie ;

Shoukry, Naglaa H. .

JOURNAL OF HEPATOLOGY, 2010, 53 (05) :805-816

[86]

Peritt D, 1998, J IMMUNOL, V161, P5821

[87] Elevated levels of interleukin-8 in serum are associated with hepatitis C virus infection and resistance to interferon therapy [J].

Polyak, SJ ;

Khabar, KSA ;

Rezeiq, M ;

Gretch, DR .

JOURNAL OF VIROLOGY, 2001, 75 (13) :6209-6211

[88] Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners [J].

Radaeva, S ;

Sun, R ;

Jaruga, B ;

Nguyen, VT ;

Tian, ZG ;

Gao, B .

GASTROENTEROLOGY, 2006, 130 (02) :435-452

[89] Genetic Variation in IL28B Is Associated With Chronic Hepatitis C and Treatment Failure: A Genome-Wide Association Study [J].

Rauch, Andri ;

Kutalik, Zoltan ;

Descombes, Patrick ;

Cai, Tao ;

Di Iulio, Julia ;

Mueller, Tobias ;

Bochud, Murielle ;

Battegay, Manuel ;

Bernasconi, Enos ;

Borovicka, Jan ;

Colombo, Sara ;

Cerny, Andreas ;

Dufour, Jean-Francois ;

Furrer, Hansjakob ;

Guenthard, Huldrych F. ;

Heim, Markus ;

Hirschel, Bernard ;

Malinverni, Raffaele ;

Moradpour, Darius ;

Muellhaupt, Beat ;

Witteck, Andrea ;

Beckmann, Jacques S. ;

Berg, Thomas ;

Bergmann, Sven ;

Negro, Francesco ;

Telenti, Amalio ;

Bochud, Pierre-Yves .

GASTROENTEROLOGY, 2010, 138 (04) :1338-U173

[90] Interaction of NK inhibitory receptor genes with HLA-C and MHC class II alleles in Hepatitis C virus infection outcome [J].

Romero, Viviana ;

Azocar, Jose ;

Zuniga, Joaquin ;

Clavijo, Olga P. ;

Terreros, Daniel ;

Gu, Xiangjun ;

Husain, Zaheed ;

Chung, Raymond T. ;

Amos, Christopher ;

Yunis, Edmond J. .

MOLECULAR IMMUNOLOGY, 2008, 45 (09) :2429-2436

← 2 3 4 5 6 7 8 9 10 11 →