Two consistently deleted regions within chromosome 1p32-pter in human non-small cell lung cancer

被引：13

作者：

Chizhikov, V

Zborovskaya, I

Laktionov, K

Delektorskaya, V

Polotskii, B

Tatosyan, A

Gasparian, A

机构：

[1] NN Blokhin Canc Res Ctr, Oncogene Regulat Lab, Moscow, Russia

[2] NN Blokhin Canc Res Ctr, Surg Dept thorac & Abdominal Oncol, Moscow, Russia

[3] NN Blokhin Canc Res Ctr, Dept Clin Pathol, Moscow, Russia

来源：

MOLECULAR CARCINOGENESIS | 2001年 / 30卷 / 03期

关键词：

allelic loss; tumor-supressor genes; chromosome; 1p; lung cancer;

D O I：

10.1002/mc.1023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Allelic losses at 1 p32-pter have been reported as frequent events in human non-small cell lung cancer (NSCLC). To further characterize the region of deletions, we studied loss of heterozygosity on a panel of 102 microdissected NSCLC samples with 20 polymorphic markers spanning 1 p32-pter. Two shortest regions of the overlap of the deletions (SROs) were found: SRO 2a (D1S417-D1S57) and SRO 2b (D1S450-D1S243), Allelic losses at either region correlated independently with advanced stage of disease and with postoperative metastasis and relapse (P<0.05), suggesting that crucial genes in these regions are involved in NSCLC progression. <(c)> 2001 Wiley-Liss. Inc.

引用

页码：151 / 158

页数：8

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