Estrogenic activity of tamoxifen and raloxifene on rat brain AMPA receptors

被引：24

作者：

Cyr, M

Morissette, M

Landry, M

Di Paolo, T

机构：

[1] Univ Laval, Med Ctr, Oncol & Mol Endocrinol Res Ctr, Ste Foy, PQ G1V 4G2, Canada

[2] Univ Laval, Fac Pharm, Ste Foy, PQ G1V 4G2, Canada

来源：

NEUROREPORT | 2001年 / 12卷 / 03期

关键词：

AMPA receptors; autoradiography; estrogen; frontal cortex; ovariectomy; menopause; raloxifene; schizophrenia; tamoxifen;

D O I：

10.1097/00001756-200103050-00021

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

We have previously shown in rats that estradiol has brain regionally specific effects on AMPA receptors. The present study investigated hormonal specificity of AMPA receptors by comparing the effect of estradiol with tamoxifen or raloxifene, which have varying effects on estrogen response in breast, bone and uterus. Ovariectomy in rats decreased uterus weight which was restored by estradiol treatment, whereas tamoxifen and raloxifene had only a weak effect. Ovariectomy left unchanged AMPA receptor specific binding in rat brain whereas estradiol, tamoxifen and raloxifene decreased it in cortical and striatal regions of ovariectomized rats. Hence. tamoxifen and raloxifene showed agonist estrogenic activity on AMPA receptors in specific brain regions, which can be dissociated from their antagonist estrogenic activity in the periphery. NeuroReport 12:535-539 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：535 / 539

页数：5

共 21 条

[1]

Regulation of GluR2 promoter activity by neurotrophic factors via a neuron-restrictive silencer element [J].