The structure and function of tenascins in the nervous system

被引：144

作者：

Joester, A

Faissner, A

机构：

[1] CNRS, Ctr Neurochim, LNDR, UPR 1325, F-67084 Strasbourg, France

[2] Dept Neurobiol, D-69120 Heidelberg, Germany

来源：

MATRIX BIOLOGY | 2001年 / 20卷 / 01期

关键词：

tenacins; glycoproteins; nervous system;

D O I：

10.1016/S0945-053X(00)00136-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The tenascins are a family of large extracellular matrix glycoproteins that comprise five known members. Three of these, tenascin-C (TN-C) tenascin-R (TN-R) and tenascin-Y (TN-Y) are expressed in specific patterns during nervous system development and are down-regulated after maturation. The expression of TN-C, the best studied member of the family, persists in restricted areas of the nervous system that exhibit neuronal plasticity and is reexpressed after lesion. Numerous studies in vitro suggest specific roles for tenascins in the nervous system involving precursor cell migration, axon growth and guidance. TN-C has been shown to occur in a large number of isoform variants generated by combinatorial variation of alternatively spliced fibronectin type III (FNIII) repeats. This finding indicates that TN-C might specify neural microenvironments, a hypothesis supported by recent analysis of TN-C knockout animals, which has begun to reveal subtle nervous system dysfunctions. (C) 2001 Elsevier Science B.V./International Society of Matrix Biology. All rights reserved.

引用

页码：13 / 22

页数：10

共 73 条

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