Epigenetic analysis of kinetochore assembly on variant human centromeres

被引：37

作者：

Warburton, PE ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Dept Human Genet, New York, NY 10029 USA

来源：

TRENDS IN GENETICS | 2001年 / 17卷 / 05期

关键词：

D O I：

10.1016/S0168-9525(01)02283-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Human centromere formation involves the assembly of the mitotic kinetochore onto chromosomal locations that contain the interphase prekinetochore, Immunofluorescent analysis of two functionally converse human centromere variants, neocentromeres and inactive centromeres, has been used to evaluate the functional significance of over 24 centromere proteins, providing important insight into the epigenetics of centromere formation and kinetochore assembly.

引用

页码：243 / 247

页数：5

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