Tramadol release from a delivery system based on alginate-chitosan microcapsules

Alginate-chitosan microcapsules to control the release of Tramadol-HCl were prepared using two different methods, In the two-stage procedure (Variant I) alginate was first pumped into a CaCl2/NaCl solution and then transferred into a chitosan solution. In the one-stage procedure (Variant R) alginate was directly pumped into a chitosan/CaCl2 solution, and different behavior could be noted in each case. The microcapsules were spherical in both variants and they swelled to a greater extent in a basic medium as compared to an acid one. The, drug release profile of Tramadol from microcapsules in simulated gastric fluid and intestinal fluid was also studied. The maximum release of Tramadol at 24 h was 64% and 86% for Variant I and II, respectively, in simulated intestinal fluid. Release, was adjusted using the power law of the semi-empirical Peppas equation in order to gain information about the release mechanism. In both cases the values of the exponent were found to be between 0.53 and 0.84 for swellable microcapsules in simulated gastric and intestinal fluids, respectively. indicating anomalous drug transport for both variants. The good results obtained with alginate-chitosan microcapsules are comparable to those of the best products so far described in the scientific bibliography and in chitosan is useful in pharmacy.