Clinicopathologic factors identify sporadic mismatch repair-defective colon cancers

被引：46

作者：

Halvarsson, Britta ^{[1
]}

Anderson, Harald ^{[3
]}

Domanska, Katarina ^{[4
]}

Lindmark, Gudrun ^{[2
]}

Nilbert, Mef ^{[4
,5
,6
]}

机构：

[1] Helsingborg Hosp, Dept Pathol & Cytol, S-25187 Helsingborg, Sweden

[2] Helsingborg Hosp, Dept Surg, S-25187 Helsingborg, Sweden

[3] Univ Lund Hosp, Dept Canc Epidemiol, S-22185 Lund, Sweden

[4] Univ Lund Hosp, Dept Oncol, S-22185 Lund, Sweden

[5] Hvidovre Univ Hosp, Clin Res Ctr, Copenhagen, Denmark

[6] Univ Copenhagen, Dept Clin Sci, Copenhagen, Denmark

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2008年 / 129卷 / 02期

关键词：

mismatch repair; microsatellite instability; tumor-infiltrating lymphocyte; morphology; histopathology;

D O I：

10.1309/0PP5GDRTXUDVKAWJ

中图分类号：

R36 [病理学];

学科分类号：

100104 [病理学与病理生理学];

摘要：

Identification of sporadic mismatch repair (MMR)-defective colon cancers is increasingly demanded for decisions on adjuvant therapies. We evaluated clinicopathologic factors for the identification of these prognostically favorable tumors. Histopathologic features in 238 consecutive colon cancers were linked to MMR status based on immunostaining and BRAF mutation status. MMR defects were identified in 22.7% of the tumors, with 46 classified as sporadic. When the clinical parameters of age, sex, and proximal tumor location were combined with the morphologic features with the highest relative risks (RRs), eg, mucinous differentiation (RR, 9.0), tumor-infiltrating lymphocytes (RR, 7.5), absence of necrosis (RR, 7.5), and expanding growth pattern (RR, 5.0) into a 7-factor index, the presence of at least 4 features identified the MMR-defective tumors with 92.3% sensitivity and 75.3% specificity and excluded 61.5% of the tumors from MMR testing. This clinicopathologic index thus successfully selects MMR-defective colon cancers.

引用

页码：238 / 244

页数：7

共 37 条

[1]

Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease [J].

Aaltonen, LA ;

Salovaara, R ;

Kristo, P ;

Canzian, F ;

Hemminki, A ;

Peltomäki, P ;

Chadwick, RB ;

Kääriäinen, H ;

Eskelinen, M ;

Järvinen, H ;

Mecklin, JP ;

de la Chapelle, A ;

Percesepe, A ;

Ahtola, H ;

Härkönen, N ;

Julkunen, R ;

Kangas, E ;

Ojala, S ;

Tulikoura, J ;

ValKamo, E .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (21) :1481-1487

[2]

Histopathological identification of colon cancer with microsatellite instability [J].

Alexander, J ;

Watanabe, T ;

Wu, TT ;

Rashid, A ;

Li, SA ;

Hamilton, SR .

AMERICAN JOURNAL OF PATHOLOGY, 2001, 158 (02) :527-535

[3]

Microsatellite instability and colorectal cancer prognosis [J].

Benatti, P ;

Gafà, R ;

Barana, D ;

Marino, M ;

Scarselli, A ;

Pedroni, M ;

Maestri, I ;

Guerzoni, L ;

Roncucci, L ;

Menigatti, M ;

Roncari, B ;

Maffei, S ;

Rossi, G ;

Ponti, G ;

Santini, A ;

Losi, L ;

Di Gregorio, C ;

Oliani, C ;

de Leon, MP ;

Lanza, G .

CLINICAL CANCER RESEARCH, 2005, 11 (23) :8332-8340

[4]

Cunningham JM, 1998, CANCER RES, V58, P3455

[5]

Mutations of the BRAF gene in human cancer [J].

Davies, H ;

Bignell, GR ;

Cox, C ;

Stephens, P ;

Edkins, S ;

Clegg, S ;

Teague, J ;

Woffendin, H ;

Garnett, MJ ;

Bottomley, W ;

Davis, N ;

Dicks, N ;

Ewing, R ;

Floyd, Y ;

Gray, K ;

Hall, S ;

Hawes, R ;

Hughes, J ;

Kosmidou, V ;

Menzies, A ;

Mould, C ;

Parker, A ;

Stevens, C ;

Watt, S ;

Hooper, S ;

Wilson, R ;

Jayatilake, H ;

Gusterson, BA ;

Cooper, C ;

Shipley, J ;

Hargrave, D ;

Pritchard-Jones, K ;

Maitland, N ;

Chenevix-Trench, G ;

Riggins, GJ ;

Bigner, DD ;

Palmieri, G ;

Cossu, A ;

Flanagan, A ;

Nicholson, A ;

Ho, JWC ;

Leung, SY ;

Yuen, ST ;

Weber, BL ;

Siegler, HF ;

Darrow, TL ;

Paterson, H ;

Marais, R ;

Marshall, CJ ;

Wooster, R .

NATURE, 2002, 417 (6892) :949-954

[6]

BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing [J].

Domingo, E ;

Laiho, P ;

Ollikainen, M ;

Pinto, M ;

Wang, L ;

French, AJ ;

Westra, J ;

Frebourg, T ;

Espín, E ;

Armengol, M ;

Hamelin, R ;

Yamamoto, H ;

Hofstra, RMW ;

Seruca, R ;

Lindblom, A ;

Peltomäki, P ;

Thibodeau, SN ;

Aaltonen, LA ;

Schwartz, S .

JOURNAL OF MEDICAL GENETICS, 2004, 41 (09) :664-668

[7]

Evidence of a preferred molecular pathway in patients with synchronous colorectal cancer [J].

Dykes, SL ;

Qui, HM ;

Rothenberger, DA ;

García-Aguilar, J .

CANCER, 2003, 98 (01) :48-54

[8]

GRAHAM DM, 1990, MODERN PATHOL, V3, P332

[9]

Phenotype of microsatellite unstable colorectal carcinomas - Well-differentiated and focally mucinous tumors and the absence of dirty necrosis correlate with microsatellite instability [J].

Greenson, JK ;

Bonner, JD ;

Ben-Yzhak, O ;

Cohen, HI ;

Miselevich, I ;

Resnick, MB ;

Trougouboff, P ;

Tomsho, LD ;

Kim, E ;

Low, M ;

Almog, R ;

Rennert, G ;

Gruber, SB .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2003, 27 (05) :563-570

[10]

Microsatellite instability analysis and/or immunostaining for the diagnosis of hereditary nonpolyposis colorectal cancer? [J].

Halvarsson, B ;

Lindblom, A ;

Rambech, E ;

Lagerstedt, K ;

Nilbert, M .

VIRCHOWS ARCHIV, 2004, 444 (02) :135-141

← 1 2 3 4 →