Irx1 and Irx2 expression in early lung development

被引：31

作者：

Becker, MB ^{[1
]}

Zülch, A ^{[1
]}

Bosse, A ^{[1
]}

Gruss, P ^{[1
]}

机构：

[1] Max Planck Inst Biophys Chem, Dept Mol Cell Biol, D-37077 Gottingen, Germany

来源：

MECHANISMS OF DEVELOPMENT | 2001年 / 106卷 / 1-2期

关键词：

mouse; trachea; Irx1; Irx2; iroquois; Gil1; Gli2; Gli3; mash; 1; lung developments; lung epithelium; lung buds; glandular periods; canalicular period;

D O I：

10.1016/S0925-4773(01)00412-9

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We describe a comparative lung expression analysis of the murine Irx1 and Irx2 genes. At embryonic day 8.5 (E8.5), the Irx1 and Irx2 expression starts in the foregut region, where the laryngo-tracheal groove will form. The expression is prominent in the lung epithelium during glandular development. It declines at the end of the canalicular phase. We further compare the Irx1 and Irx2 expression domains to Gli1, 2, 3 and Mash1. Their homologues in Drosophila melanogaster are known as regulative partners of the iroquois complex. The Irx and Gli genes are coexpressed in the developing lungs at the same time. Their transcripts are not localised in the same cells but adjacent to each other in either mesenchymal or epithelial structures. It is thought that the lung development is regulated by the mesenchymal/epithelial interactions. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：155 / 158

页数：4

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