Organocatalytic asymmetric α-bromination of aldehydes and ketones

被引：95

作者：

Bertelsen, S ^{[1
]}

Halland, N ^{[1
]}

Bachmann, S ^{[1
]}

Marigo, M ^{[1
]}

Braunton, A ^{[1
]}

Jorgensen, KA ^{[1
]}

机构：

[1] Aarhus Univ, Dept Chem, Ctr Catalysis, Danish Natl Res Fdn, DK-8000 Aarhus, Denmark

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 38期

关键词：

D O I：

10.1039/b509366j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first organocatalytic enantioselective alpha-bromination of aldehydes and ketones is presented; a C-2-symmetric diphenylpyrrolidine catalyst afforded the alpha-brominated aldehydes in good yields and up to 96% ee, while ketones were alpha-brominated by a C-2-symmetric imidazolidine in up to 94% ee; furthermore, the organocatalytic enantioselective alpha-iodination of aldehydes is also demonstrated to proceed with up to 89% ee.

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收藏

页码：4821 / 4823

页数：3

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