Biodegradable polymer matrix nanocomposites for tissue engineering: A review

被引：845

作者：

Armentano, I. ^{[1
]}

Dottori, M. ^{[1
]}

Fortunati, E. ^{[1
]}

Mattioli, S. ^{[1
]}

Kenny, J. M. ^{[1
,2
]}

机构：

[1] Univ Perugia, NIPLAB, UdR INSTM, Mat Engn Ctr, Terni, Italy

[2] CSIC, Inst Polymer Sci & Technol, Madrid, Spain

来源：

POLYMER DEGRADATION AND STABILITY | 2010年 / 95卷 / 11期

关键词：

Biodegradable polymers; Nanofillers; Nanocomposites; Biodegradation; Tissue engineering; WALLED CARBON NANOTUBES; PLASMA SURFACE MODIFICATION; IN-VITRO DEGRADATION; MARROW STROMAL CELLS; MECHANICAL-PROPERTIES; HYDROLYTIC DEGRADATION; SILVER NANOPARTICLES; COMPOSITE SCAFFOLDS; ELECTRICAL-CONDUCTIVITY; ELECTROSPUN NANOFIBERS;

D O I：

10.1016/j.polymdegradstab.2010.06.007

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理];

摘要：

Nanocomposites have emerged in the last two decades as an efficient strategy to upgrade the structural and functional properties of synthetic polymers. Aliphatic polyesters as polylactide (PLA), poly(glycolides) (PGA), poly(epsilon-caprolactone) (PCL) have attracted wide attention for their biodegradability and biocompatibility in the human body. A logic consequence has been the introduction of organic and inorganic nanofillers into biodegradable polymers to produce nanocomposites based on hydroxyapatite, metal nanoparticles or carbon nanotructures, in order to prepare new biomaterials with enhanced properties. Consequently, the improvement of interfacial adhesion between the polymer and the nanostructures has become the key technique in the nanocomposite process. In this review, different results on the fabrication of nanocomposites based on biodegradable polymers for specific field of tissue engineering are presented. The combination of bioresorbable polymers and nanostructures open new perspectives in the self-assembly of nanomaterials for biomedical applications with tuneable mechanical, thermal and electrical properties. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2126 / 2146

页数：21

共 274 条

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